Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction

HFCAS OpenIR

	Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction
其他题名	Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction
	Gao Lei 1; Zhao Zhifeng 1; Guo Fengfu 1; Liu Yan 2; Guo Jianhua 3; Zhao Yang 3; Wang Zhong 3
	2017
发表期刊	ASIAN JOURNAL OF ANDROLOGY
ISSN	1008-682X
摘要	The purpose of our meta-analysis is to examine the associations between three single nucleotide polymorphisms of endothelial nitric oxide synthase (eNOS) gene, G894T, intron 4 and T-786C, and the risk of erectile dysfunction. An electronic database search was performed to identify case-control studies reporting the association between single nucleotide polymorphisms of eNOS gene and erectile dysfunction. Stringent inclusion and exclusion criteria were employed to select high-quality studies for this meta-analysis. Comprehensive Meta-analysis 2.0 software (Biostat Inc., Englewood, New Jersey, USA) was used for statistical analysis of the data extracted from the selected studies. From the initial 203 articles retrieved from database search, this meta-analysis finally selected 12 high-quality case-control studies that conformed to our inclusion criteria. The 12 studies contained a total of 1962 patients with erectile dysfunction and 1752 healthy controls. The results of our meta-analysis showed that G894T correlated with an increased risk erectile dysfunction under both the allele and dominant models (allele: OR = 1.556, 95% Cl = 1.064-2.275, P = 0.023; dominant: OR = 1.613, 95% Cl = 1.050-2.476, P = 0.029). A similar association was found between T-786C and erectile dysfunction under the allele model (OR = 1.679, 95% Cl = 1.341-2.102, P 0.05). Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.
其他摘要	The purpose of our meta-analysis is to examine the associations between three single nucleotide polymorphisms of endothelial nitric oxide synthase (eNOS) gene, G894T, intron 4 and T-786C, and the risk of erectile dysfunction. An electronic database search was performed to identify case-control studies reporting the association between single nucleotide polymorphisms of eNOS gene and erectile dysfunction. Stringent inclusion and exclusion criteria were employed to select high-quality studies for this meta-analysis. Comprehensive Meta-analysis 2.0 software (Biostat Inc., Englewood, New Jersey, USA) was used for statistical analysis of the data extracted from the selected studies. From the initial 203 articles retrieved from database search,this meta-analysis finally selected 12 high-quality case-control studies that conformed to our inclusion criteria. The 12 studies contained a total of 1962 patients with erectile dysfunction and 1752 healthy controls. The results of our meta-analysis showed that G894T correlated with an increased risk erectile dysfunction under both the allele and dominant models (allele: OR = 1.556, 95% CI = 1.064-2.275, P= 0.023; dominant: OR = 1.613, 95% CI = 1.050-2.476, P= 0.029). A similar association was found between T-786C and erectile dysfunction under the allele model (OR = 1.679, 95% CI = 1.341-2.102, P 0.05). Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.
关键词	CORONARY-ARTERY-DISEASE ENOS G894T POLYMORPHISM INTRON-4 VNTR SEXUAL DYSFUNCTION METABOLIC SYNDROME GENE METAANALYSIS POPULATION MEN HETEROGENEITY endothelial nitric oxide synthase erectile dysfunction G894T intron 4 meta-analysis single nucleotide polymorphism
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:5978518
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/46793
专题	中国科学院合肥物质科学研究院
作者单位	1.Linyi Peoples Hosp, Department Urinary Surg, Linyi 276000, Peoples R China 2.中国科学院合肥物质科学研究院肿瘤医院 3.上海交通大学 4.复旦大学
推荐引用方式 GB/T 7714	Gao Lei,Zhao Zhifeng,Guo Fengfu,et al. Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction[J]. ASIAN JOURNAL OF ANDROLOGY,2017,19.
APA	Gao Lei.,Zhao Zhifeng.,Guo Fengfu.,Liu Yan.,Guo Jianhua.,...&Wang Zhong.(2017).Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction.ASIAN JOURNAL OF ANDROLOGY,19.
MLA	Gao Lei,et al."Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction".ASIAN JOURNAL OF ANDROLOGY 19(2017).