A new prognostic histopathologic classification of nasopharyngeal carcinoma

HFCAS OpenIR

	A new prognostic histopathologic classification of nasopharyngeal carcinoma
其他题名	A new prognostic histopathologic classification of nasopharyngeal carcinoma
	2016
发表期刊	CHINESE JOURNAL OF CANCER
ISSN	1000-467X
摘要	Background: The current World Health Organization (WHO) classification of nasopharyngeal carcinoma ( NPC) conveys little prognostic information. This study aimed to propose an NPC histopathologic classification that can potentially be used to predict prognosis and treatment response.
其他摘要	Background The current World Health Organization (WHO) classification of nasopharyngeal carcinoma (NPC) conveys little prognostic information. This study aimed to propose an NPC histopathologic classification that can potentially be used to predict prognosis and treatment response. Methods We initially developed a histopathologic classification based on the morphologic traits and cell differentiation of tumors of 2716 NPC patients who were identified at Sun Yat-sen University Cancer Center (SYSUCC) (training cohort). Then, the proposed classification was applied to 1702 patients (retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients (prospective validation cohort) from SYSUCC. The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes. We used Cox proportional hazards models to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS). Results The 5-year OS rates for all NPC patients who were diagnosed with epithelial carcinoma (EC; 3708 patients), mixed sarcomatoid-epithelial carcinoma (MSEC; 1247 patients), sarcomatoid carcinoma (SC; 823 patients), and squamous cell carcinoma (SCC; 253 patients) were 79.4%, 70.5%, 59.6%, and 42.6%, respectively ( P <0.001). In multivariate models, patients with MSEC had a shorter OS than patients with EC (HR=1.44, 95% CI=1.27–1.62), SC (HR=2.00, 95% CI=1.76–2.28), or SCC (HR=4.23, 95% CI=3.34–5.38). Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC (HR=0.67, 95% CI=0.56–0.80), MSEC (HR=0.58, 95% CI=0.49–0.75), and possibly for those with SCC (HR=0.63; 95% CI=0.40–0.98), but not for patients with SC (HR=0.97, 95% CI=0.74–1.28). Conclusions The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associated with a poor prognosis.
关键词	CONCURRENT CISPLATIN-RADIOTHERAPY ADJUVANT CHEMOTHERAPY RANDOMIZED-TRIAL STAGING SYSTEM CANCER CHEMORADIOTHERAPY METAANALYSIS CHINA SURVIVAL UNION Nasopharyngeal carcinoma Pathologic classification Prognosis
收录类别	CSCD
语种	英语
资助项目	[National High Technology Research and Development Program of China (863 Program)] ; [Chinese State Key Basic Research Project] ; [National Natural Science Foundation of China]
CSCD记录号	CSCD:5747589
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/48137
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. A new prognostic histopathologic classification of nasopharyngeal carcinoma[J]. CHINESE JOURNAL OF CANCER,2016,35.
APA	(2016).A new prognostic histopathologic classification of nasopharyngeal carcinoma.CHINESE JOURNAL OF CANCER,35.
MLA	"A new prognostic histopathologic classification of nasopharyngeal carcinoma".CHINESE JOURNAL OF CANCER 35(2016).