呼吸运动幅度对静态IMRT剂量分布的影响研究

HFCAS OpenIR

	呼吸运动幅度对静态IMRT剂量分布的影响研究
其他题名	Effect of amplitude of respiratory movements on dose distribution of static intensity-modulated radiotherapy
	刘苓苓1 ; 费振乐 2; 李兵兵 1; 王宏志1
	2016
发表期刊	中华放射肿瘤学杂志
ISSN	1004-4221
摘要	目的研究呼吸运动幅度对静态IMRT剂量分布的影响，为受其影响的剂量修正提供指导。方法采用QUASAR程控呼吸运动仪带动二维矩阵模拟人体上下方向呼吸运动，采集不同呼吸运动幅度等中心层面剂量分布。通过Verisofl软件及绝对剂量分析，分析采集数据与计划剂量分布、绝对剂量百分误差、射野通过率。结果呼吸运动对靶区内剂量分布影响较小，主要使运动方向边缘靶区外剂量偏高；当呼吸运动幅度〈6mm时γ通过率能满足临床剂量验证需求，〉8mm时随着呼吸幅度的增加γ通过率变小，不能满足临床需求。结论呼吸运动对静态IMRT技术的影响主要是模糊效应，可通过适当补偿方法确定静态IMRT周期性呼吸运动肿瘤的可行性。呼吸运动方向靶区边缘正常组织实际受量高于计划评价，制定放疗计划时应尽可能降低周围正常组织受量。对呼吸运动幅度较大者，应采取措施减小呼吸幅度提高靶区受照。
其他摘要	Objective To study the effect of amplitude of respiratory movements on dose distribution of static intensity-modulated radiotherapy （IMRT） , and to provide a basis for dose correction against respiratory movements. Methods A two-dimensional matrix driven by the QUASAR program- controlled respiratory movement instrument was used to simulate human respiratory movements in the head/ foot direction. The dose distribution was evaluated on the isocenter plane with different amplitudes of respiratory movements. The Verisoft software and absolute dose analysis were used to analyze dose distribution, percentage errors of absolute dose, and passing rates of radiation field for both collected data and planned dose distribution. Results In spite of little effect on dose distribution in target volume, respiratory movements increased the dose outside the marginal target volume along the movement direction. When the respiratory amplitude was lower than 6 ram, the passing rate of γ distribution met the requirement of clinical dose verification; when the respiratory amplitude was larger than 8 mm, the passing rate of γ distribution was reduced with the increasing respiratory amplitude and fell below the clinical standard. Conclusions Respiratory movements have a blurring effect on static IMRT. It is possible to introduce some compensation methods to static IMRT in the treatment of tumor with periodic respiratory movements. The normal tissue at the edge of target volume along the respiratory movement direction is exposed to a higher radiation dose than expected. Therefore, the radiation close for the normal tissue around target volume should be made as low as possible in the radiotherapy plan. For the patients with relatively large respiratory amplitude, action should be taken to lower respiratory amplitude and elevate the radiation dose in target volume.
关键词	呼吸运动幅度静态IMRT 剂量分布 QUASAR程控呼吸运动仪
收录类别	CSCD
语种	中文
CSCD记录号	CSCD:5689621
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/50842
专题	中国科学院合肥物质科学研究院
作者单位	1.中国科学院合肥物质科学研究院肿瘤医院 2.中国人民解放军第一零五医院肿瘤诊疗中心 3.中国科学院合肥物质科学研究院肿瘤医院 4.中国科学院合肥物质科学研究院肿瘤医院
第一作者单位	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	刘苓苓,费振乐,李兵兵,等. 呼吸运动幅度对静态IMRT剂量分布的影响研究[J]. 中华放射肿瘤学杂志,2016,025.
APA	刘苓苓,费振乐,李兵兵,&王宏志.(2016).呼吸运动幅度对静态IMRT剂量分布的影响研究.中华放射肿瘤学杂志,025.
MLA	刘苓苓,et al."呼吸运动幅度对静态IMRT剂量分布的影响研究".中华放射肿瘤学杂志 025(2016).