Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance

HFCAS OpenIR

	Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance
其他题名	Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance
	2014
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
摘要	Objective: Vascular-targeted therapy is gradually becoming more appealing for patients with lung cancer. It is unclear whether vascular endothelial growth factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1) can be biomarkers for clinical treatment. We aimed to investigate the expression levels of VEGFR2 and NRP-1 in human non-small cell lung cancer (NSCLC) and their clinical significance by observing patient prognosis.
其他摘要	Objective Vascular-targeted therapy is gradually becoming more appealing for patients with lung cancer. It is unclear whether vascular endothelial growth factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1) can be biomarkers for clinical treatment. We aimed to investigate the expression levels of VEGFR2 and NRP-1 in human non-small cell lung cancer (NSCLC) and their clinical significance by observing patient prognosis. Methods VEGFR2 and NRP-1 were assessed by immunohistochemistry (IHC) in 40 patients with NSCLC and in 10 patients with benign lesions of lung; kinase insert domain receptor (KDR) and NRP-1 copy number gain (CNG) was assessed by fluorescence in situ hybridization (FISH). The distributions of overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method and compared between groups by log-rank test. Results Rates of positive immunostaining for VEGFR2 and NRP-1 were 58% and 55%, respectively. KDR and NRP-1 CNG (+) were detected in 32.5% and 30% of tumors, respectively. Levels of both VEGFR2 and NRP-1 in lung tumors were significantly different than in the control tissue (χ 2 =11.22, P=0.001; χ 2 =9.82, P=0.001, respectively); similar results were obtained using CNGs (χ 2 =4.39, P=0.036; χ 2 =3.95, P=0.046, respectively). Statistically significant correlations were observed with histological grade, clinical TNM stage and the lymph node status (P<0.05), but not age, gender or pathology type (P>0.05). VEGFR2 showed a strong correlation with NRP-1 (Rs=0.68, P=0.00); similar results were observed with KDR and NRP-1 CNG (Rs=0.32, P=0.04). Significant differences in OS and PFS were observed between the groups with higher VEGFR2 and NRP-1 and those with lower expression (P<0.05). Conclusions According to these data, VEGFR2 and NRP-1 are highly expressed in NSCLC. We can conclude that they play a key role in NSCLC occurrence, development and metastasis and are associated with patient prognosis (P<0.05 for OS and PFS). This information will be beneficial for clinical anti-angiogenic treatment in NSCLC.
关键词	ENDOTHELIAL GROWTH-FACTOR TUMOR-CELLS CARCINOMA NEUROPILIN-1 RECEPTORS VEGF(165) Non-small cell lung cancer (NSCLC) vascular endothelial growth factor receptor 2 (VEGFR2) neuropilin-1 (NRP-1) fluorescence in situ hybridization (FISH)
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Ministry of Health of China] ; [Jiangsu Natural Science Foundation of China]
CSCD记录号	CSCD:5322015
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/51820
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance[J]. CHINESE JOURNAL OF CANCER RESEARCH,2014,26.
APA	(2014).Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance.CHINESE JOURNAL OF CANCER RESEARCH,26.
MLA	"Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance".CHINESE JOURNAL OF CANCER RESEARCH 26(2014).