A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women

HFCAS OpenIR

	A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women
其他题名	A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women
	2018
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
摘要	Objective: The automated breast ultrasound system (ABUS) is a potential method for breast cancer detection; however, its diagnostic performance remains unclear. We conducted a hospital-based multicenter diagnostic study to evaluate the clinical performance of the ABUS for breast cancer detection by comparing it to handheld ultrasound (HHUS) and mammography (MG).
其他摘要	Objective： The automated breast ultrasound system（ABUS） is a potential method for breast cancer detection;however, its diagnostic performance remains unclear. We conducted a hospital-based multicenter diagnostic study to evaluate the clinical performance of the ABUS for breast cancer detection by comparing it to handheld ultrasound（HHUS） and mammography（MG）.Methods： Eligible participants underwent HHUS and ABUS testing; women aged 40–69 years additionally underwent MG. Images were interpreted using the Breast Imaging Reporting and Data System（BI-RADS）.Women in the BI-RADS categories 1–2 were considered negative. Women classified as BI-RADS 3 underwent magnetic resonance imaging to distinguish true-and false-negative results. Core aspiration or surgical biopsy was performed in women classified as BI-RADS 4–5, followed by a pathological diagnosis. Kappa values and agreement rates were calculated between ABUS, HHUS and MG.Results： A total of 1,973 women were included in the final analysis. Of these, 1,353（68.6%） and 620（31.4%）were classified as BI-RADS categories 1–3 and 4–5, respectively. In the older age group, the agreement rate and Kappa value between the ABUS and HHUS were 94.0% and 0.860（P〈0.001）, respectively; they were 89.2% and0.735（P〈0.001） between the ABUS and MG, respectively. Regarding consistency between imaging and pathology results, 78.6% of women classified as BI-RADS 4–5 based on the ABUS were diagnosed with precancerous lesions or cancer; which was 7.2% higher than that of women based on HHUS. For BI-RADS 1–2, the false-negative rates of the ABUS and HHUS were almost identical and were much lower than those of MG.Conclusions： We observed a good diagnostic reliability for the ABUS. Considering its performance for breast cancer detection in women with high-density breasts and its lower operator dependence, the ABUS is a promising option for breast cancer detection in China.
关键词	SERVICES TASK-FORCE MAMMOGRAPHIC DENSITY DIGITAL MAMMOGRAPHY RISK-FACTORS US MORTALITY UPDATE Automated breast ultrasound system breast neoplasms China
收录类别	CSCD
语种	英语
资助项目	[GE Healthcare]
CSCD记录号	CSCD:6249902
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/53811
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women[J]. CHINESE JOURNAL OF CANCER RESEARCH,2018,30.
APA	(2018).A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women.CHINESE JOURNAL OF CANCER RESEARCH,30.
MLA	"A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women".CHINESE JOURNAL OF CANCER RESEARCH 30(2018).