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Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity | |
其他题名 | Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma:Preliminary report on tumor response and acute toxicity |
2006-01-01 | |
发表期刊 | WORLD JOURNAL OF GASTROENTEROLOGY |
ISSN | 1007-9327 |
摘要 | AIM: Tumor response and normal tissue toxicity of seven-day-per-week continuous accelerated irradiation (CAIR) for patients with esophageal carcinoma were evaluated and compared to conventional irradiation (CR). |
其他摘要 | AIM: Tumor response and normal tissue toxicity of seven-day-per-week continuous accelerated irradiation (CAIR) for patients with esophageal carcinoma were evaluated and compared to conventional irradiation (CR).METHODS: Sixty patients with squamous cell carcinoma of the esophagus were randomized into two groups:the CAIR group (30 patients) and the CR group (30 pa(RT) with 2 Gy/fraction per day at 7 d/wk with a total dose of 50-70 Gy (average dose 64.2 Gy). The overall time of irradiation was 3.6-5.0 wk (average 4.6 wk). RT in the CR group was 2 Gy/fraction per day at 5 d/wk with a total dose of 40-70 Gy (average dose 61.7 Gy).The overall time of irradiation was 4.0-7.0 wk (average 6.4wk).RESULTS: The data showed that the immediate tumor response to RT was better in the CAIR group than in the CR group. Efficiency rates (CR plus PR) were 82.8%(24/29) and 58.6% (17/29), respectively (P = 0.047). In both groups the incidences of esophagitis and tracheitis were insignificant (P = 0.376, 0.959), and no patient received toxicity that could not be tolerated.CONCLUSION: CAIR shortens overall treatment time and is well tolerated by patients. It may be superior to CR in enhancing the local response of tumor, but its remote effect for esophageal carcinoma awaits further follow-up. |
关键词 | CELL LUNG-CANCER NECK-CANCER HYPERFRACTIONATED RADIOTHERAPY POSTOPERATIVE RADIOTHERAPY INTERIM-REPORT ADVANCED HEAD FRACTIONATION CHART esophageal carcinoma continuous accelerated irradiation conventional irradiation toxicity overall treatment time |
收录类别 | CSCD |
语种 | 英语 |
CSCD记录号 | CSCD:2571783 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/57348 |
专题 | 中国科学院合肥物质科学研究院 |
推荐引用方式 GB/T 7714 | . Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2006,12. |
APA | (2006).Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity.WORLD JOURNAL OF GASTROENTEROLOGY,12. |
MLA | "Randomized clinical trial on seven-day-per-week continuous accelerated irradiation for patients with esophageal carcinoma: Preliminary report on tumor response and acute toxicity".WORLD JOURNAL OF GASTROENTEROLOGY 12(2006). |
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