LncRNAs in DNA damage response and repair in cancer cells

HFCAS OpenIR

	LncRNAs in DNA damage response and repair in cancer cells
其他题名	LncRNAs in DNA damage response and repair in cancer cells
	2018
发表期刊	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN	1672-9145
摘要	In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/repair response network, which can induce cell cycle arrest, apoptosis, or DNA repair. Chemo-and radiation therapies, which act primarily through the induction of DNA damage, are the most commonly used therapies for cancer. Impairment in the DNA damage response and repair system that protect cells from persistent DNA damage can affect the therapeutic efficacy of cancer. To date, accumulating evidence has suggested that long non-coding RNAs (lncRNAs) are involved in the regulation of the DNA damage/repair network. LncRNAs have been demonstrated to be master regulators of the genome at the transcriptional and post-transcriptional levels and play a key role in many physiological and pathological processes of cells. In this review, we will discuss the function of lncRNAs in regulating the cellular response to DNA damage.
其他摘要	In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/ repair response network, which can induce cell cycle arrest, apoptosis, or DNA repair. Chemo- and radiation therapies, which act primarily through the induction of DNA damage, are the most commonly used therapies for cancer. Impairment in the DNA damage response and repair system that protect cells from persistent DNA damage can affect the therapeutic efficacy of cancer. To date, accumulating evidence has suggested that long non-coding RNAs (IncRNAs) are involved in the regulation of the DNA damage/repair network. LncRNAs have been demonstrated to be master regulators of the genome at the transcriptional and post-transcriptional levels and play a key role in many physiological and pathological processes of cells. In this review, we will discuss the function of IncRNAs in regulating the cellular response to DNA damage.
关键词	LONG NONCODING RNA CISPLATIN-INDUCED NEPHROTOXICITY STRAND BREAK REPAIR NASOPHARYNGEAL CARCINOMA HOMOLOGOUS RECOMBINATION MESENCHYMAL TRANSITION REPLICATION STRESS PANCREATIC-CANCER COLORECTAL-CANCER GENOME INTEGRITY DNA damage response apoptosis cell cycle cancer lncRNA
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China] ; [Hunan Provincial Natural Science Foundation of China] ; [Scientific Research Foundation of the Health and Family Planning Commission of Hunan Province]
CSCD记录号	CSCD:6252625
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/57966
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. LncRNAs in DNA damage response and repair in cancer cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2018,50.
APA	(2018).LncRNAs in DNA damage response and repair in cancer cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,50.
MLA	"LncRNAs in DNA damage response and repair in cancer cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 50(2018).