Total synthesis of snake toxin α-bungarotoxin and its analogues by hydrazide-based native chemical ligation

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	Total synthesis of snake toxin α-bungarotoxin and its analogues by hydrazide-based native chemical ligation
其他题名	Total synthesis of snake toxin α-bungarotoxin and its analogues by hydrazide-based native chemical ligation
	2018
发表期刊	Chinese Chemical Letters
ISSN	1001-8417
摘要	Display omitted
其他摘要	Nicotinic acetylcholine receptors (nAChRs) play important roles in intercellular communications of nerve cells. a-Bungarotoxins (aBtx) is a moderator for the nAChRs. Chemical synthesis provides a promising way to access aBtx and their analogues. Here, we reported a new method for α-bungarotoxin by combining Fmoc-SPPS and peptide hydrazide based ligation strategy. The two-segment ligation method may enable efficient synthesis of aBtx analogues. These synthetic toxin peptides are useful tools for development of imaging or therapeutic reagents.
关键词	Chemical synthesis Native chemical ligation Peptide hydrazide Nicotinic acetylcholine receptors
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:6275733
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/58581
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Total synthesis of snake toxin α-bungarotoxin and its analogues by hydrazide-based native chemical ligation[J]. Chinese Chemical Letters,2018,29.
APA	(2018).Total synthesis of snake toxin α-bungarotoxin and its analogues by hydrazide-based native chemical ligation.Chinese Chemical Letters,29.
MLA	"Total synthesis of snake toxin α-bungarotoxin and its analogues by hydrazide-based native chemical ligation".Chinese Chemical Letters 29(2018).