The prognostic role of PRUNE2 in leiomyosarcoma

HFCAS OpenIR

	The prognostic role of PRUNE2 in leiomyosarcoma
其他题名	The prognostic role of PRUNE2 in leiomyosarcoma
	2013
发表期刊	CHINESE JOURNAL OF CANCER
ISSN	1000-467X
摘要	PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2/OBSCN two-gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor. However, the association between PRUNE2 expression and prognosis in leiomyosarcoma is poorly understood. In this study, we evaluated the prognostic role of PRUNE2 in leiomyosarcoma. PRUNE2 expression was detected using immunohistochemistry in 30 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from MD Anderson Cancer Center, and high expression was detected in 36.7% (11/30) of the samples. To validate these results, immunohistochemistry was performed on another cohort of 45 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from Tianjin Medical University Cancer Institute & Hospital, and high PRUNE2 protein expression was detected in 37.8% (17/45) of the samples. Moreover, elevated PRUNE2 expression was significantly associated with tumor size (P = 0.03) and hemorrhage/cyst (P = 0.014), and was an independent favorable prognostic factor for overall survival in leiomyosarcoma patients from Tianjin Medical University Cancer Institute & Hospital (P < 0.05). These data suggest that increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma.
其他摘要	PRUNE2 plays an important role in regulating tumor cell differentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2 P = 0.03) and hemorrhage P = 0.014), and was an independent favorable prognostic factor for overall survival in leiomyosarcoma patients from Tianjin Medical University Cancer Institute & Hospital ( P < 0.05). These data suggest that increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma.
关键词	SOFT-TISSUE LEIOMYOSARCOMA BCH DOMAIN EXPRESSION TUMORS BNIP2 BMCC1 GENE Leiomyosarcoma PRUNE2 survival prognosis
收录类别	CSCD
语种	英语
资助项目	[National Nature Science Foundation of China] ; [University Cancer Foundation via the Sister Institution Network Fund (SINF) at the Tianjin Medical University Cancer Institute & Hospital (TMUCIH)] ; [Fudan University Shanghai Cancer Center (FUSCC)] ; [University of Texas MD Anderson Cancer Center (UTMDACC)] ; [Changjiang Scholars and Innovative Research Team in University (PCSIRT) in China] ; [National Key Scientific and Technological Project]
CSCD记录号	CSCD:5007773
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/62773
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. The prognostic role of PRUNE2 in leiomyosarcoma[J]. CHINESE JOURNAL OF CANCER,2013,32.
APA	(2013).The prognostic role of PRUNE2 in leiomyosarcoma.CHINESE JOURNAL OF CANCER,32.
MLA	"The prognostic role of PRUNE2 in leiomyosarcoma".CHINESE JOURNAL OF CANCER 32(2013).