Efficacy of minimally invasive therapies on unresectable pancreatic cancer

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	Efficacy of minimally invasive therapies on unresectable pancreatic cancer
其他题名	Efficacy of minimally invasive therapies on unresectable pancreatic cancer
	2013
发表期刊	CHINESE JOURNAL OF CANCER
ISSN	1000-467X
摘要	For patients with unresectable pancreatic cancer, current chemotherapies have negligible survival benefits. Thus, developing effective minimally invasive therapies is currently underway. This study was conducted to evaluate the efficacy of transarterial chemoembolization plus radiofrequency ablation and/or I-125 radioactive seed implantation on unresectable pancreatic cancer. We analyzed the outcome of 71 patients with unresectable pancreatic carcinoma who underwent chemoembolization plus radiofrequency ablation and/or radioactive seed implantation. Of the 71 patients, the median survival was 11 months, and the 1-, 2-, and 3-year overall survival rates were 32.4%, 9.9%, and 6.6%, respectively. Patients who had no metastasis, who had oligonodular liver metastases ( 3 lesions) had median survival of 12, 18, and 8 months, respectively, and 1-year overall survival rates of 50.0%, 68.8%, and 5.7%, respectively. Although the survival of patients without liver metastases was worse than that of patients with oligonodular liver metastasis, the result was not significant (P = 0.239). In contrast, the metastasis-negative patients had significantly better survival than did patients with multinodular liver metastases (P < 0.001). Patients with oligonodular liver lesions had a significanthg longer median survival than did patients with multinodular lesions (P < 0.001). In conclusion, combined minimally invasive therapies had good efficacy on unresectable pancreatic cancer and resulted in a good control of liver metastases. In addition, the number of liver metastases was a significant factor in predicting prognosis and response to treatment.
其他摘要	For patients with unresectable pancreatic cancer, current chemotherapies have negligible survival benefits. Thus, developing effective minimally invasive therapies is currently underway. This study was conducted to evaluate the efficacy of transarterial chemoembolization plus radiofrequency ablation and 125 I radioactive seed implantation on unresectable pancreatic cancer. We analyzed the outcome of 71 patients with unresectable pancreatic carcinoma who underwent chemoembolization plus radiofrequency ablation and P = 0.239). In contrast, the metastasis-negative patients had significantly better survival than did patients with multinodular liver metastases ( P < 0.001). Patients with oligonodular liver lesions had a significanthg longer median survival than did patients with multinodular lesions ( P < 0.001). In conclusion, combined minimally invasive therapies had good efficacy on unresectable pancreatic cancer and resulted in a good control of liver metastases. In addition, the number of liver metastases was a significant factor in predicting prognosis and response to treatment.
关键词	LIVER METASTASES NASOPHARYNGEAL CARCINOMA RADIOFREQUENCY ABLATION CHEMOTHERAPY GEMCITABINE TUMORS MANAGEMENT SURVIVAL Pancreatic cancer minimally invasive therapies transarterial chemoembolization radiofrequency ablation median survival
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4870551
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/62791
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Efficacy of minimally invasive therapies on unresectable pancreatic cancer[J]. CHINESE JOURNAL OF CANCER,2013,32.
APA	(2013).Efficacy of minimally invasive therapies on unresectable pancreatic cancer.CHINESE JOURNAL OF CANCER,32.
MLA	"Efficacy of minimally invasive therapies on unresectable pancreatic cancer".CHINESE JOURNAL OF CANCER 32(2013).