Angioarchitecture and CD133(+) tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma

HFCAS OpenIR

	Angioarchitecture and CD133(+) tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma
其他题名	Angioarchitecture and CD133~+ tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma
	2011-01-01
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
摘要	Angioarchitecture plays an important role in the malignant development of intracranial hemangiopericytoma. It remains poorly understood whether high frequency of hemorrhage during clinical surgery for intracranial hemangiopericytoma is associated with angioarchitecture. The present study utilized hematoxylin-eosin staining, and immunohistochemical staining with epithelial membrane antigen, vimentin, CD34, von Willebrand factor (vWF) and CD133 to observe characteristics of angioarchitecture. In addition, silver stains were used to demonstrate changes in reticular fibers in the wall of vessel channels in intracranial hemangiopericytoma and meningioma. Five patterns of angioarchitecture were identified in intracranial hemangiopericytoma, namely tumor cell islands, vasculogenic mimicry, mosaic blood vessels, sprouting angiogenesis, and intussusceptive angiogenesis. Several CD133(+) tumor cells were found to form tumor cell islands. A connection between vWF(+) and vWF(-) channels was detected in the pattern of intussusceptive angiogenesis, and some vimentin(+) tumor cells were embedded in the periodic acid-Schiff positive channel wall. Incomplete threads of reticular fibers formed the walls of larger pseudo-vascular channels and some tumor clumps or scattered tumor cells were detected "floating" in them. The angioarchitecture, specific markers and reticular fibers of intracranial hemangiopericytoma were significantly different from meningioma. Angioarchitecture provides a functional vascular network for vascular evolution in intracranial hemangiopericytoma and contributes to significant intra-operative bleeding.
其他摘要	Angioarchitecture plays an important role in the malignant development of intracranial hemangiopericytoma. It remains poorly understood whether high frequency of hemorrhage during clinical surgery for intracranial hemangiopericytoma is associated with angioarchitecture. The present study utilized hematoxylin-eosin staining, and immunohistochemical staining with epithelial membrane antigen, vimentin, CD34, von Willebrand factor (vWF) and CD133 to observe characteristics of angioarchitecture. In addition, silver stains were used to demonstrate changes in reticular fibers in the wall of vessel channels in intracranial hemangiopericytoma and meningioma. Five patterns of angioarchitecture were identified in intracranial hemangiopericytoma, namely tumor cell islands, vasculogenic mimicry, mosaic blood vessels, sprouting angiogenesis, and intussusceptive angiogenesis. Several CD133~+ tumor cells were found to form tumor cell islands. A connection between vWF~+ and vWF~- channels was detected in the pattern of intussusceptive angiogenesis, and some vimentin~+ tumor cells were embedded in the periodic acid-Schiff positive channel wall. Incomplete threads of reticular fibers formed the walls of larger pseudo-vascular channels and some tumor clumps or scattered tumor cells were detected “floating” in them. The angioarchitecture, specific markers and reticular fibers of intracranial hemangiopericytoma were significantly different from meningioma. Angioarchitecture provides a functional vascular network for vascular evolution in intracranial hemangiopericytoma and contributes to significant intra-operative bleeding.
关键词	MENINGEAL HEMANGIOPERICYTOMA EMBOLIZATION ANGIOGENESIS RADIOSURGERY RADIOTHERAPY RESECTION FEATURES intracranial hemangiopericytoma angioarchitecture tumor cell islands vasculogenic mimicry mosaic blood vessels, sprouting angiogenesis intussusceptive angiogenesis meningioma CD133
收录类别	CSCD
语种	英语
资助项目	[Science and Technology Projects in Liaoning Province]
CSCD记录号	CSCD:4414792
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/63795
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Angioarchitecture and CD133(+) tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma[J]. NEURAL REGENERATION RESEARCH,2011,6.
APA	(2011).Angioarchitecture and CD133(+) tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma.NEURAL REGENERATION RESEARCH,6.
MLA	"Angioarchitecture and CD133(+) tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma".NEURAL REGENERATION RESEARCH 6(2011).