Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features

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	Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features
其他题名	Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features
	2010-01-01
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
摘要	Background S100A8 and S100A9 are two members of the S100 protein family characterized by the presence of two Ca(2+)-binding sites of the EF-hand type Previous studies suggested that the whole S100 family displays significant functions in tumor growth, progression and invasion This study aimed to determine the expression of the two indices of the family, S100A8 and S100A9, in lung cancer tissues and normal lung tissues and its correlation with clinical features.
其他摘要	Background S100A8 and S100A9 are two members of the S100 protein family characterized by the presence of two Ca~(2+)-binding sites of the EF-hand type. Previous studies suggested that the whole S100 family displays significant functions in tumor growth, progression and invasion. This study aimed to determine the expression of the two indices of the family, S100A8 and S100A9, in lung cancer tissues and normal lung tissues and its correlation with clinical features. Methods A total of 60 cases with a variety of clinical data that were diagnosed with different histological subtypes of lung cancer were investigated. Semi-quantitative reverse transcriptase-PCR (Sq-Rt-PCR) and immunohistochemical staining of cancer, adjacent and peripheral lung tissues were executed to distinguish the expression patterns of S100A8 and S100A9 and to further clarify their correlation with clinical features. Results Immunohistochemical staining of both proteins showed a significant up-regulation in lung cancer tissue (S100A8, S100A9, P<0.0001), and PCR revealed that the levels of S100A8 and S100A9 expression were significantly higher in lung cancer tissues (S100A8 P=0.002/0.004; S100A9 P=0.022/0.026). The higher expression was found to be correlated with the clinical characteristics of adenocarcinoma, inflammation and stage IV lesion. Conclusions S100A8, S100A9 up-regulation was found in the lung adenocarcinoma and end stage lung cancer tissue, the correlation of which with their higher expression in inflammatory lung tissues may indicate the collaborative effect of inflammation on the progression of cancer
关键词	CALCIUM-BINDING PROTEINS HUMAN PROSTATE CANCER MARKERS TISSUE S100A8 S100A9 inflammation lung odenocarcinoma
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3966074
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/64177
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features[J]. CHINESE MEDICAL JOURNAL,2010,123.
APA	(2010).Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features.CHINESE MEDICAL JOURNAL,123.
MLA	"Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features".CHINESE MEDICAL JOURNAL 123(2010).