The formation of intracellular nanoparticles correlates with cisplatin resistance

HFCAS OpenIR

	The formation of intracellular nanoparticles correlates with cisplatin resistance
其他题名	The formation of intracellular nanoparticles correlates with cisplatin resistance
	2015
发表期刊	SCIENCE CHINA-MATERIALS
ISSN	2095-8226
摘要	Patients treated with the cisplatin often develop strong resistance to the drug after prolonged treatments, ultimately resulting in limited clinical efficacy. One of the possible mechanisms is that the internalized compound may be inactivated before getting access to the nucleus where cisplatin forms a complex with the genomic DNA and triggers a cell death program. However, the nature and intracellular fate of inactivated cisplatin is poorly illustrated. In the present study, we reported for the first time the presence of platinum nanoparticles (Pt-NPs) in the cytoplasm of cells treated with cisplatin. Further analysis also evidenced a correlation of the increased intracellular Pt-NPs formation with cisplatin resistance, and confirmed the process was glutathione S-transferase relevant. Our data suggest that tumor cells may develop cisplatin resistance by converting the drug into less toxic intracellular Pt-NPs, thereby impeding the drug from targeting its substrates.
其他摘要	Patients treated with the cisplatin often develop strong resistance to the drug after prolonged treatments, ultimately resulting in limited clinical efficacy. One of the possible mechanisms is that the internalized compound may be inactivated before getting access to the nucleus where cisplatin forms a complex with the genomic DNA and triggers a cell death program. However, the nature and intracellular fate of inactivated cisplatin is poorly illustrated. In the present study, we reported fo the first time the presence of platinum nanoparticles (Pt-NPs) in the cytoplasm of cells treated with cisplatin. Further analysis also evidenced a correlation of the increased intracellular Pt-NPs formation with cisplatin resistance, and confirmed the process was glutathione S-transferase relevant. Our data suggest that tumor cells may develop cisplatin resistance by converting the drug into less toxic intracellular Pt-NPs, thereby impeding the drug from targeting its substrates.
关键词	GLUTATHIONE-S-TRANSFERASE SQUAMOUS-CELL CARCINOMA LOCALLY ADVANCED HEAD PLATINUM NANOPARTICLES NECK-CANCER MOLECULAR-MECHANISMS DRUG-RESISTANCE CHEMOTHERAPY CYTOTOXICITY NANOMATERIALS
收录类别	CSCD
语种	英语
资助项目	[National Key Basic Research Program of China] ; [National Natural Science Foundation of China (NSFC)] ; [Special Funds of National Natural Science Foundation of China For Basic Research Projects of Scientific Instruments] ; [Special Project on the Development of National Key Scientific Instruments and Equipment of China] ; [China Postdoctoral Science Foundation]
CSCD记录号	CSCD:5530252
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/66524
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. The formation of intracellular nanoparticles correlates with cisplatin resistance[J]. SCIENCE CHINA-MATERIALS,2015,58.
APA	(2015).The formation of intracellular nanoparticles correlates with cisplatin resistance.SCIENCE CHINA-MATERIALS,58.
MLA	"The formation of intracellular nanoparticles correlates with cisplatin resistance".SCIENCE CHINA-MATERIALS 58(2015).