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Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis | |
其他题名 | Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis * |
2012-01-01 | |
发表期刊 | JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B |
ISSN | 1673-1581 |
摘要 | To investigate the protective effects and mechanisms of action of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis (SAP). |
其他摘要 | Objective: To investigate the protective effects and mechanisms of action of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis (SAP). Methods: The rats were divided into sham-operated, model control, dexamethasone treated, and Salvia miltiorrhiza treated groups. At 3, 6, and 12 h after operation, the mortality rate of different groups, pathological changes, Bcl-2-associated X protein (Bax) and nuclear factor-κB (NF-κB) protein expression levels in multiple organs (the pancreas, liver, kidneys, and lungs), toll-like receptor 4 (TLR-4) protein levels (only in the liver), intercellular adhesion molecule 1 (ICAM-1) protein levels (only in the lung), and terminal deoxynucleotidy transferase mediated deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) staining expression levels, as well as the serum contents of amylase, glutamate-pyruvate transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), blood urea nitrogen (BUN), and creatinine (CREA) were observed. Results: The mortality rate of the dexamethasone treated group was significantly lower than that of the model control group ( P <0.05). The pathological changes in multiple organs in the two treated groups were relieved to different degrees ( P <0.05 and P <0.01, respectively), the expression levels of Bax and NF-κB proteins, and apoptotic indexes of multiple organs were reduced ( P <0.05 and P <0.01, respectively). The contents of amylase, GPT, GOT, BUN, and CREA in the two treated groups were significantly lower than those in model control groups ( P <0.05 and P <0.01, respectively). The expression level of ICAM-1 protein in the lungs (at 3 and 12 h) in the dexamethasone treated group was significantly lower than that in the Salvia miltiorrhiza treated group ( P <0.05). The serum contents of CREA (at 12 h) and BUN (at 6 h) of the Salvia miltiorrhiza treated group were significantly lower than those in the dexamethasone treated group ( P <0.05). Conclusions: Both dexamethasone and Salvia miltiorrhiza can reduce the inflammatory reaction, regulate apoptosis, and thus protect multiple organs of rats with SAP. |
关键词 | CERULEIN-INDUCED PANCREATITIS KAPPA-B INJURY APOPTOSIS PERMEABILITY ACTIVATION EXTRACT INFLAMMATION RESVERATROL INVOLVEMENT Dexamethasone Salvia miltiorrhiza Pancreatitis Multiple organs Rats Apoptosis NF-kB TLR-4 ICAM-1 Tissue microarrays |
收录类别 | CSCD |
语种 | 英语 |
资助项目 | [Foundation for the Excellent Middle-Aged and Talented Young Persons of Zhejiang Province "151", China] |
CSCD记录号 | CSCD:4674772 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.hfcas.ac.cn:8080/handle/334002/67577 |
专题 | 中国科学院合肥物质科学研究院 |
推荐引用方式 GB/T 7714 | . Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2012,13. |
APA | (2012).Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,13. |
MLA | "Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 13(2012). |
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