Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis

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	Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis
其他题名	Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis *
	2012-01-01
发表期刊	JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
ISSN	1673-1581
摘要	To investigate the protective effects and mechanisms of action of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis (SAP).
其他摘要	Objective: To investigate the protective effects and mechanisms of action of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis (SAP). Methods: The rats were divided into sham-operated, model control, dexamethasone treated, and Salvia miltiorrhiza treated groups. At 3, 6, and 12 h after operation, the mortality rate of different groups, pathological changes, Bcl-2-associated X protein (Bax) and nuclear factor-κB (NF-κB) protein expression levels in multiple organs (the pancreas, liver, kidneys, and lungs), toll-like receptor 4 (TLR-4) protein levels (only in the liver), intercellular adhesion molecule 1 (ICAM-1) protein levels (only in the lung), and terminal deoxynucleotidy transferase mediated deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) staining expression levels, as well as the serum contents of amylase, glutamate-pyruvate transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), blood urea nitrogen (BUN), and creatinine (CREA) were observed. Results: The mortality rate of the dexamethasone treated group was significantly lower than that of the model control group ( P <0.05). The pathological changes in multiple organs in the two treated groups were relieved to different degrees ( P <0.05 and P <0.01, respectively), the expression levels of Bax and NF-κB proteins, and apoptotic indexes of multiple organs were reduced ( P <0.05 and P <0.01, respectively). The contents of amylase, GPT, GOT, BUN, and CREA in the two treated groups were significantly lower than those in model control groups ( P <0.05 and P <0.01, respectively). The expression level of ICAM-1 protein in the lungs (at 3 and 12 h) in the dexamethasone treated group was significantly lower than that in the Salvia miltiorrhiza treated group ( P <0.05). The serum contents of CREA (at 12 h) and BUN (at 6 h) of the Salvia miltiorrhiza treated group were significantly lower than those in the dexamethasone treated group ( P <0.05). Conclusions: Both dexamethasone and Salvia miltiorrhiza can reduce the inflammatory reaction, regulate apoptosis, and thus protect multiple organs of rats with SAP.
关键词	CERULEIN-INDUCED PANCREATITIS KAPPA-B INJURY APOPTOSIS PERMEABILITY ACTIVATION EXTRACT INFLAMMATION RESVERATROL INVOLVEMENT Dexamethasone Salvia miltiorrhiza Pancreatitis Multiple organs Rats Apoptosis NF-kB TLR-4 ICAM-1 Tissue microarrays
收录类别	CSCD
语种	英语
资助项目	[Foundation for the Excellent Middle-Aged and Talented Young Persons of Zhejiang Province "151", China]
CSCD记录号	CSCD:4674772
引用统计	被引频次：5[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/67577
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2012,13.
APA	(2012).Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis.JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,13.
MLA	"Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis".JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 13(2012).