Helicobacter pylori infection and esophageal cancer risk: An updated meta-analysis

HFCAS OpenIR

	Helicobacter pylori infection and esophageal cancer risk: An updated meta-analysis
其他题名	Helicobacter pylori infection and esophageal cancer risk:An updated meta-analysis
	2013
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
摘要	AIM: To clarify the association between Helicobacter pylori (H. pylori) infection and the risk of esophageal carcinoma through a meta-analysis of published data.
其他摘要	AIM:To clarify the association between Helicobacter pylori(H.pylori)infection and the risk of esophageal carcinoma through a meta-analysis of published data.METHODS:Studies which reported the association between H.pylori infection and esophageal cancer published up to June 2013 were included.The odds ratios(ORs)and corresponding 95%CIs of H.pyloriinfection on esophageal cancer with respect to health control groups were evaluated.Data were extracted independently by two investigators and discrepancies were resolved by discussion with a third investigator.The statistical software,STATA(version 12.0),was applied to investigate heterogeneity among individual studies and to summarize the studies.A meta-analysis was performed using a fixed-effect or random-effect method,depending on the absence or presence of significant heterogeneity.RESULTS:No significant association between H.pylori infection and esophageal squamous cell carcinoma(ESCC)risk was found in the pooled overall population(OR=0.97,95%CI:0.76-1.24).However,significant associations between H.pylori infection and ESCC risk were found in Eastern subjects(OR=0.66,95%CI:0.43-0.89).Similarly,cytotoxin-associated gene-A(CagA)positive strains of infection may decrease the risk of ESCC in Eastern subjects(OR=0.77,95%CI:0.65-0.92),however,these associations were not statistically significant in Western subjects(OR=1.26,95%CI:0.97-1.63).For esophageal adenocarcinoma(EAC)the summary OR for H.pylori infection and CagA positive strains of infection were 0.59(95%CI:0.51-0.68)and 0.56(95%CI:0.45-0.70),respectively.CONCLUSION:H.pylori infection is associated with a decreased risk of ESCC in Eastern populations and a decreased risk of EAC in the overall population.
关键词	SQUAMOUS-CELL CARCINOMA GASTRIC ATROPHY ADENOCARCINOMA ASSOCIATION REFLUX SEROPOSITIVITY STRAINS CAGA PREVALENCE METAPLASIA Helicobacter pylori Esophageal carcinoma Cancer risk Meta-analysis
收录类别	CSCD
语种	英语
资助项目	[China Postdoctoral Science Foundation] ; [Zhejiang Provincial Postdoctoral Science Foundation] ; [National Natural Science Foundation of China] ; [Zhejiang Provincial Natural Science Foundation] ; [Wu Jieping Medical Foundation]
CSCD记录号	CSCD:5009762
引用统计
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/68494
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Helicobacter pylori infection and esophageal cancer risk: An updated meta-analysis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19.
APA	(2013).Helicobacter pylori infection and esophageal cancer risk: An updated meta-analysis.WORLD JOURNAL OF GASTROENTEROLOGY,19.
MLA	"Helicobacter pylori infection and esophageal cancer risk: An updated meta-analysis".WORLD JOURNAL OF GASTROENTEROLOGY 19(2013).