A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals

HFCAS OpenIR

	A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals
其他题名	ahighlyefficientandtumorvasculartargetingtherapeutictechniquewithsizeexpansiblegadofullerenenanocrystals
	2015-01-01
发表期刊	SCIENCE CHINA-MATERIALS
ISSN	2095-8226
摘要	It has long been a dream to achieve tumor targeting therapy that can efficiently reduce the toxicity and severe side effects of conventional antitumor chemotherapeutic agents. Taking advantage of the abnormalities of tumor vasculature, we demonstrate here a new powerful tumor vascular-targeting therapeutic technique for solid cancers that applies advanced nanotechnology to cut off the nutrient supply of tumor cells by physically destroying the abnormal tumor blood vessels. Water soluble magnetic Gd@C-82 nanocrystals of the chosen sizes are deliberately designed with abilities to penetrate into the leaky tumor blood vessels. By triggering the radiofrequency induced phase transition of gadofullerene nanocrystals while extravasating the tumor blood vessel, the explosive structural change of nanoparticles generates a devastating impact on abnormal tumor blood vessels, resulting in a rapid and extensive ischemia necrosis and shrinkage of the tumors. This unprecedented target-specific physiotherapy is found to work perfectly for advanced and refractory solid tumors.
其他摘要	It has long been a dream to achieve tumor targeting therapy that can efficiently reduce the toxicity and severe side effects of conventional antitumor chemotherapeutic agents. Taking advantage of the abnormalities of tumor vasculature, we demonstrate here a new powerful tumor vascular-targeting therapeutic technique for solid cancers that applies advanced nanotechnology to cut off the nutrient supply of tumor cells by physically destroying the abnormal tumor blood vessels. Water soluble magnetic Gd@C_(82) nanocrystals of the chosen sizes are deliberately designed with abilities to penetrate into the leaky tumor blood vessels. By triggering the radiofrequency induced phase transition of gadofullerene nanocrystals while extravasating the tumor blood vessel, the explosive structural change of nanoparticles generates a devastating impact on abnormal tumor blood vessels, resulting in a rapid and extensive ischemia necrosis and shrinkage of the tumors. This unprecedented target-specific physiotherapy is found to work perfectly for advanced and refractory solid tumors.
关键词	IMAGING CONTRAST AGENT CANCER-THERAPY BLOOD-VESSELS DISRUPTING AGENTS NANOPARTICLES NANOMEDICINE HYPERTHERMIA AGGREGATION RETENTION NANOWIRES
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:5551309
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/69294
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals[J]. SCIENCE CHINA-MATERIALS,2015,58.
APA	(2015).A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals.SCIENCE CHINA-MATERIALS,58.
MLA	"A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals".SCIENCE CHINA-MATERIALS 58(2015).