Supervillin promotes tumor angiogenesis in liver cancer

doi:10.3892/or.2020.7621

HFCAS OpenIR

	Supervillin promotes tumor angiogenesis in liver cancer
	Zhao, Chenggang 1,2; Zhao, Zhiyang 1,2; Wang, Zhen 1,3; Hu, Lizhu 1,2; Wang, Hongzhi1,4 ; Fang, Zhiyou 1,4
	2020-08-01
发表期刊	ONCOLOGY REPORTS
ISSN	1021-335X
通讯作者	Fang, Zhiyou(z.fang@cmpt.ac.cn)
摘要	Tumor angiogenesis is a hallmark of liver cancer and is necessary for tumor growth and progression. Supervillin (SVIL) is highly expressed and implicated in several malignant processes of liver cancer. However, the functional relationships between SVIL and tumor angiogenesis in liver cancer have not yet been fully elucidated. The present study was based on bioinformatics analysis, patient tissue sample detection, three-dimensional simulated blood vessel formation, a series of cytological experiments and mouse models. The results demonstrated the important role of SVIL in the progression of malignant liver cancer and tumor angiogenesis, both in terms of vasculogenic mimicry (VM) and endothelium-dependent vessel (EDV) development. SVIL knockdown inhibited VM formation and induced tumor cell apoptosis via the VEGF-p38 signaling axis and through various VM-associated transcriptional factors, including vascular endothelial-cadherin, matrix metalloproteinase 9/12 and migration-inducing protein 7. SVIL may therefore be considered a potential tumor vascular biomarker and a promising therapeutic target for patients with liver cancer.
关键词	supervillin vascular endothelial growth factor p38 vascular mimicry liver cancer
DOI	10.3892/or.2020.7621
关键词[WOS]	ENDOTHELIAL GROWTH-FACTOR ; P38 MAP KINASE ; VASCULOGENIC MIMICRY ; HEPATOCELLULAR-CARCINOMA ; F-ACTIN ; ACTIVATION ; CADHERIN ; PROTEIN ; CELLS ; PROLIFERATION
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31571433] ; National Natural Science Foundation of China[81773131] ; National Natural Science Foundation of China[81872066] ; Anhui Provincial Natural Science Foundation[1608085MH180] ; Anhui Provincial Natural Science Foundation[1808085QH272] ; Innovative program of the Development Foundation of Hefei Center for Physical Science and Technology[2017FXCX008] ; CASHIPS Director's Fund[YZJJ201704]
项目资助者	National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation ; Innovative program of the Development Foundation of Hefei Center for Physical Science and Technology ; CASHIPS Director's Fund
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000567188700024
出版者	SPANDIDOS PUBL LTD
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/70373
专题	中国科学院合肥物质科学研究院
通讯作者	Fang, Zhiyou
作者单位	1.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Stem Cell & Regenerat Med, Guangzhou Inst Biomed & Hlth, Hefei 230088, Anhui, Peoples R China 4.Chinese Acad Sci, Hefei Canc Hosp, Dept Pathol & Lab Med, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Chenggang,Zhao, Zhiyang,Wang, Zhen,et al. Supervillin promotes tumor angiogenesis in liver cancer[J]. ONCOLOGY REPORTS,2020,44.
APA	Zhao, Chenggang,Zhao, Zhiyang,Wang, Zhen,Hu, Lizhu,Wang, Hongzhi,&Fang, Zhiyou.(2020).Supervillin promotes tumor angiogenesis in liver cancer.ONCOLOGY REPORTS,44.
MLA	Zhao, Chenggang,et al."Supervillin promotes tumor angiogenesis in liver cancer".ONCOLOGY REPORTS 44(2020).