Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database

doi:10.7150/jca.46201

HFCAS OpenIR

	Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database
	Piao, Yongfeng 1,2,3,4; Jiang, Chuner 1,5,6; Yan, Fengqin 1,2,3,4; Ye, Zhimin 1,2,3,4; Fu, Zhenfu 1,2,3,4; Jiang, Haitao 1,7,8; Jiang, Yangming 9; Wang, Yuezhen 1,2,3,4; Wang, Fangzheng 1,2,3,4
	2020
发表期刊	JOURNAL OF CANCER
ISSN	1837-9664
通讯作者	Wang, Yuezhen(wangyz@zjcc.org.cn) ; Wang, Fangzheng(wangfz76@126.com)
摘要	Purpose: Currently, the optimal treatment regimens for older nasopharyngeal carcinoma (NPC) patients remained unclear. The aim of this retrospective study is to investigate therapeutic patterns and survival outcomes for a cohort of older NPC patients receiving radiation therapy (RT) with or without chemotherapy (CT). Methods: The clinical data of 529 patients with aged >= 65 years and NPC, who were identified within the Surveillance, Epidemiology, and End Results (SEER) registry (years 2004-2015), were collected and retrospectively reviewed. Among these patients, 74 patients treated with RT alone and 455 cases were administrated for RT plus CT. Kaplan-Meier analysis was used to evaluate overall survival (OS) and cancer-specific survival (CSS). The differences in OS and CSS were compared using Log-rank test. Results: The estimated OS and CSS rates at 5 years were 48.9% and 59.6%, respectively. Univariate analysis indicated that age, histology, T stage, and clinical stage were independent prognosticators of OS and CSS, while treatment option was only associated with OS. Multivariate analysis demonstrated that age, T stage, histology, and therapeutic strategy were correlated with OS, while age, T stage and histology were independent prognostic factors of CSS. Subgroup analyses showed that the combination of RT and CT yielded better OS and CSS in patients with stage T3 or N2 or III. Conclusion: Among these NPC patients with aged >= 65 years reported in the SEER database, treatment with RT plus CT provided longer OS than those treated with radiation therapy alone. Moreover, the combination of RT and CT obtained favorable OS and CSS in NPC patient stage T3 or N2 or III.
关键词	nasopharyngeal carcinoma older therapeutic pattern survival prognosis
DOI	10.7150/jca.46201
关键词[WOS]	ELDERLY-PATIENTS ; PHASE-III ; CONCURRENT CHEMORADIOTHERAPY ; RADIOTHERAPY ; CANCER ; SURVIVAL ; CHEMOTHERAPY
收录类别	SCI
语种	英语
资助项目	Medical and Health Science and Technology Program of Zhejiang Province[2020KY084] ; Medical and Health Science and Technology Program of Zhejiang Province[2019KY041] ; Medical and Health Science and Technology Program of Zhejiang Province[2013KYB033] ; Medical and Health Science and Technology Program of Zhejiang Province[2009B026] ; Medical and Health Science and Technology Program of Zhejiang Province[2006A016] ; Medical and Health Science and Technology Program of Zhejiang Province[2005B012] ; Medical and Health Science and Technology Program of Zhejiang Province[2004B014] ; National Natural Science Foundation of China[81502647]
项目资助者	Medical and Health Science and Technology Program of Zhejiang Province ; National Natural Science Foundation of China
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000554984800003
出版者	IVYSPRING INT PUBL
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/70965
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Yuezhen; Wang, Fangzheng
作者单位	1.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China 3.Zhejiang Canc Hosp, Dept Radiat Oncol, Zhejiang Hangzhou, Hangzhou 310022, Zhejiang, Peoples R China 4.Key Lab Radiat Oncol Zhejiang Prov, Hangzhou 310022, Zhejiang, Peoples R China 5.Univ Chinese Acad Sci, Dept Breast Tumor Surg, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 6.Zhejiang Canc Hosp, Dept Breast Tumor Surg, Hangzhou 310022, Zhejiang, Peoples R China 7.Univ Chinese Acad Sci, Dept Radiol, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 8.Zhejiang Canc Hosp, Dept Radiol, Hangzhou 310022, Zhejiang, Peoples R China 9.Chinese Acad Sci, Dept Didital Earth, Inst Remote Sensing & Didital Earth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Piao, Yongfeng,Jiang, Chuner,Yan, Fengqin,et al. Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database[J]. JOURNAL OF CANCER,2020,11.
APA	Piao, Yongfeng.,Jiang, Chuner.,Yan, Fengqin.,Ye, Zhimin.,Fu, Zhenfu.,...&Wang, Fangzheng.(2020).Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database.JOURNAL OF CANCER,11.
MLA	Piao, Yongfeng,et al."Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database".JOURNAL OF CANCER 11(2020).