HFCAS OpenIR
Oxygen-enriched Fe3O4/Gd2O3 nanopeanuts for tumor-targeting MRI and ROS-triggered dual-modal cancer therapy through platinum (IV) prodrugs delivery
Zhang, Guilong1; Zhang, Li3,4; Si, Yuanchun5; Li, Qingdong1; Xiao, Jianmin2; Wang, Bin1; Liang, Chaozhao3,4; Wu, Zhengyan2; Tian, Geng1
2020-05-15
Source PublicationCHEMICAL ENGINEERING JOURNAL
ISSN1385-8947
Corresponding AuthorLiang, Chaozhao(liang_chaozhao@ahmu.edu.cn) ; Wu, Zhengyan(zywu@ipp.ac.cn) ; Tian, Geng(tiangeng@bzmc.edu.cn)
AbstractIn this study, we designed a novel peanut probe that could load oxygen molecules and platinum(IV) prodrug (GINP-Pt) to elicit ferroptosis and apoptosis in cancer cells. In addition, transferrin-labeled amino polyethylene glycol (Tf-PEG-NH2) was equipped to GINP-Pt to obtain targeting and pH-responsive ability. When the system enters cancer cells, platinum(IV) can be released and reduced to platinum(II) by depleting glutathione (GSH), resulting in a ROS increase. Meanwhile, Tf-PGINP-Pt deliver abundant oxgen molecules into cancer cells, significantly elevating oxygen levels. Moreover, generated platinum(II) can activate nicotinamide adenine dinucleotide phosphate oxidases (NOXs), accelerating the conversion of oxygen to superoxide anions and enhancing downstream H2O2 levels. Next, Fe2+/Fe3+ ions released from Tf-PGINP-Pt rapidly converted H2O2 into highly toxic center dot OH, causing DNA and mitochondrial membrane damage, resulting in cell ferroptosis. Notably, platinum (II) can coordinate with DNA bases and form Pt-DNA adducts, inhibiting DNA replication and inducing cell apoptosis. In addition, the contrast superimposed effect originated from Gd2O3 and Fe3O4 in Tf-PGINP-Pt endows accurate diagnostic capability for tumor identification, achieving MRI-guided dual-modal cancer therapy. Therefore, this work provides an unique and clinically promising strategy for accurate diagnosis and effective therapy of cancer.
KeywordNanopeanut probe Theranostics Superimposed effect Ferroptosis Apoptosis
DOI10.1016/j.cej.2020.124269
WOS KeywordIRON-OXIDE NANOPARTICLES ; RELAXATION-TIMES ; SPIN-LATTICE ; CHEMOTHERAPY ; CISPLATIN ; AGENT ; NANOCRYSTALS ; DIAGNOSIS ; BRAIN ; T-1
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of Anhui Province[1808085MB38] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; Science and Technology Major Project of Anhui Province[17030701051] ; Anhui Science and Technology Plan Project[1604a0802082] ; Anhui Science and Technology Plan Project[1401045013] ; Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Key Research and Development Plan of Shandong Province[2018GSF118230] ; Key Project of Provincial Natural Science Research Project of Anhui Colleges[KJ2019A0278] ; Supporting Project for Distinguished Young Scholar of Anhui Colleges[gxyqZD2019018] ; Anhui Provincial Institutes for Translational Medicine[2017ZHYX02]
Funding OrganizationNatural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; Science and Technology Major Project of Anhui Province ; Anhui Science and Technology Plan Project ; Taishan Scholars Construction Engineering ; Shandong Provincial Natural Science Foundation ; Key Research and Development Plan of Shandong Province ; Key Project of Provincial Natural Science Research Project of Anhui Colleges ; Supporting Project for Distinguished Young Scholar of Anhui Colleges ; Anhui Provincial Institutes for Translational Medicine
WOS Research AreaEngineering
WOS SubjectEngineering, Environmental ; Engineering, Chemical
WOS IDWOS:000545646800040
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.hfcas.ac.cn:8080/handle/334002/71198
Collection中国科学院合肥物质科学研究院
Corresponding AuthorLiang, Chaozhao; Wu, Zhengyan; Tian, Geng
Affiliation1.Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat State Adm, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
3.Anhui Med Univ, Inst Urol, Affiliated Hosp 1, Dept Urol, Hefei 230022, Anhui, Peoples R China
4.Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei 230022, Anhui, Peoples R China
5.Anhui Med Univ, Key Lab Oral Dis Res Anhui Prov, Dept Dent Implant Ctr, Stomatol Hosp & Coll, Hefei 230032, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Guilong,Zhang, Li,Si, Yuanchun,et al. Oxygen-enriched Fe3O4/Gd2O3 nanopeanuts for tumor-targeting MRI and ROS-triggered dual-modal cancer therapy through platinum (IV) prodrugs delivery[J]. CHEMICAL ENGINEERING JOURNAL,2020,388.
APA Zhang, Guilong.,Zhang, Li.,Si, Yuanchun.,Li, Qingdong.,Xiao, Jianmin.,...&Tian, Geng.(2020).Oxygen-enriched Fe3O4/Gd2O3 nanopeanuts for tumor-targeting MRI and ROS-triggered dual-modal cancer therapy through platinum (IV) prodrugs delivery.CHEMICAL ENGINEERING JOURNAL,388.
MLA Zhang, Guilong,et al."Oxygen-enriched Fe3O4/Gd2O3 nanopeanuts for tumor-targeting MRI and ROS-triggered dual-modal cancer therapy through platinum (IV) prodrugs delivery".CHEMICAL ENGINEERING JOURNAL 388(2020).
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