The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion

doi:10.21037/gs-20-478

HFCAS OpenIR

	The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion
	Zhu, Mengting 1; Zheng, Weihui 2,3,4; Xiang, Yangfeng 2,3,4; Gu, Jialei 2,3,4; Wang, Kejing 2,3,4; Shang, Jinbiao 2,3,4
	2020-06-01
发表期刊	GLAND SURGERY
ISSN	2227-684X
通讯作者	Shang, Jinbiao(shangjb@zjcc.org.cn)
摘要	Background: This study aims to explore the predictive factors of central lymph node metastasis (CLNM) in patients with papillary thyroid microcarcinoma (PTMC) without capsule invasion. Methods: From January 2016 to October 2018, 1,622 patients with PTMC, who underwent surgical treatment at Zhejiang Cancer Hospital, were enrolled in the present study. A model of multivariate logistic regression was developed to find the variables that were independently associated with CLNM. The results were presented in the odds ratio (OR) with a 95% confidence interval (CI). The nomogram for predicting CLNM was developed based on the results of the multivariate logistic regression analysis. The distance (distance >0) from tumor to capsule is defined as the shortest distance from the tumor boundary to the capsule or trachea. Result: The multivariate logistic regression analysis indicated that age, gender, tumor maximum diameter, tumor mean diameter, and tumor volume were independently associated with CLNM. In the 692 cases without capsular invasion, the distance from the capsule was not correlated to the CLNM. The joint model, which included age, gender, tumor volume, and capsular invasion, were analyzed using the ROC curve. The cut-off point for the prediction of CLNM was defined as a value of 0.208. The area under the ROC curve was 0.687, the sensitivity was 65.4%, and the specificity was 63.3%. Conclusions: Gender, age, maximum diameter, mean diameter, tumor volume, and capsular invasion were independently associated with the CLNM. When there was no capsular invasion, the distance between the tumor and capsule was not correlated to the CLNM, suggesting that considering whether the tumor is dose to the capsule may not be necessary for low-risk PTMC.
关键词	Papillary thyroid microcarcinoma (PTMC) distance thyroid capsule central lymph node metastasis predictive factors
DOI	10.21037/gs-20-478
关键词[WOS]	RISK-FACTORS ; PATHOLOGICAL PREDICTORS ; SONOGRAPHIC FEATURES ; ACTIVE SURVEILLANCE ; DISSECTION ; RECURRENCE ; MANAGEMENT ; FREQUENCY ; PATTERN ; CANCER
收录类别	SCI
语种	英语
资助项目	Zhejiang Provincial Natural Science Foundation of China[LY20H160007]
项目资助者	Zhejiang Provincial Natural Science Foundation of China
WOS研究方向	Surgery
WOS类目	Surgery
WOS记录号	WOS:000544808800016
出版者	AME PUBL CO
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.hfcas.ac.cn:8080/handle/334002/94797
专题	中国科学院合肥物质科学研究院
通讯作者	Shang, Jinbiao
作者单位	1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Head & Neck Surg, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 4.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Mengting,Zheng, Weihui,Xiang, Yangfeng,et al. The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion[J]. GLAND SURGERY,2020,9.
APA	Zhu, Mengting,Zheng, Weihui,Xiang, Yangfeng,Gu, Jialei,Wang, Kejing,&Shang, Jinbiao.(2020).The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion.GLAND SURGERY,9.
MLA	Zhu, Mengting,et al."The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion".GLAND SURGERY 9(2020).