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HFCAS OpenIR
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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：198/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：86/31  |  提交时间：2019/06/17
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl) phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 131, 页码: 107-125
作者:  Liang, Qianmao;  Chen, Yongfei;  Yu, Kailin;  Chen, Cheng;  Zhang, Shouxiang;  Wang, Aoli;  Wang, Wei;  Wu, Hong;  Liu, Xiaochuan;  Wang, Beilei;  Wang, Li;  Hu, Zhenquan;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Yun, Cai-Hong;  Liu, Jing
收藏  |  浏览/下载：53/0  |  提交时间：2018/07/26
Btk  Irreversible Inhibitor  Kinase Inhibitor  Structure-activity Relationship  B-cell Lymphoma  
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-10
作者:  Wu, Hong;  Huang, Qiong;  Qi, Ziping;  Chen, Yongfei;  Wang, Aoli;  Chen, Cheng;  Liang, Qianmao;  Wang, Jinghua;  Chen, Wensheng;  Dong, Jin;  Yu, Kailin;  Hu, Chen;  Wang, Wenchao;  Liu, Xiaochuan;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Li, Xiaoxiang;  Gray, Nathanael S.;  Liu, Jing;  Wei, Wei;  Liu, Qingsong
浏览  |  Adobe PDF(3966Kb)  |  收藏  |  浏览/下载：131/67  |  提交时间：2018/07/04
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17305/7526  |  提交时间：2018/07/04
Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 18, 页码: 8456-8472
作者:  Li, Binhua;  Wang, Aoli;  Liu, Juan;  Qi, Ziping;  Liu, Xiaochuan;  Yu, Kailin;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Wang, Wenchao;  Wu, Jiaxin;  Hu, Zhenquan;  Ye, Ling;  Zou, Fengming;  Liu, Feiyang;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shaojuan;  Bai, Mingfeng;  Zhang, Shanchun;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(2856Kb)  |  收藏  |  浏览/下载：1411/1299  |  提交时间：2017/11/21
Simultaneous inhibition of Vps34 kinase would enhance PI3K delta inhibitor cytotoxicity in the B-cell malignancies 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 33, 页码: 53515-53525
作者:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Liu, Juanjuan;  Zou, Fengming;  Chen, Cheng;  Zhao, Zheng;  Deng, Yuanxin;  Wu, Hong;  Qi, Ziping;  Wang, Beilei;  Wang, Li;  Liu, Feiyang;  Xu, Yunhe;  Wang, Wenchao;  Fernandes, Stacey M.;  Stone, Richard M.;  Galinsky, Ilene A.;  Brown, Jennifer R.;  Loh, Teckpeng;  Griffin, James. D.;  Zhang, Shanchun;  Weisberg, Ellen L.;  Zhang, Xin;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(7625Kb)  |  收藏  |  浏览/下载：101/38  |  提交时间：2017/11/21
Pi3k Delta  Vps34  Combination  Chronic Lymphatic Leukemia  Acute Myeloid Leukemia  
Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 22, 页码: 32641-32651
作者:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Chen, Cheng;  Liu, Juanjuan;  Zhao, Zheng;  Wu, Hong;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Wu, Jiaxin;  Liu, Feiyang;  Fernandes, Stacey M.;  Adamia, Sophia;  Stone, Richard M.;  Galinsky, Ilene A.;  Brown, Jennifer R.;  Griffin, James D.;  Zhang, Shanchun;  Loh, Teckpeng;  Zhang, Xin;  Wang, Wenchao;  Weisberg, Ellen L.;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(5138Kb)  |  收藏  |  浏览/下载：86/30  |  提交时间：2017/11/16
Pi3k Delta  Leukemia  B-cell Malignances  Pi3k  Kinase Inhibitors  
Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 20, 页码: 29131-29142
作者:  Wang, Aoli;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Qi, Ziping;  Wang, Wenchao;  Yu, Kailin;  Liu, Xiaochuan;  Zou, Fengming;  Zhao, Zheng;  Wu, Jiaxin;  Liu, Juan;  Liu, Feiyang;  Wang, Li;  Stone, Richard M.;  Galinksy, Ilene A.;  Griffin, James D.;  Zhang, Shanchun;  Weisberg, Ellen L.;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(4786Kb)  |  收藏  |  浏览/下载：135/35  |  提交时间：2017/11/16
Acute Myeloid Leukemia  Flt3-itd  Akt  A6745763  Flt3-ligand