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HFCAS OpenIR

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Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：86/31  |  提交时间：2019/06/17
A MOF-derived self-template strategy toward cobalt phosphide electrodes with ultralong cycle life and high capacity 期刊论文
JOURNAL OF MATERIALS CHEMISTRY A, 2017, 卷号: 5, 期号: 21, 页码: 10321-10327
作者:  Xia, Guoliang;  Su, Jianwei;  Li, Mengsi;  Jiang, Peng;  Yang, Yang;  Chen, Qianwang
浏览  |  Adobe PDF(1412Kb)  |  收藏  |  浏览/下载：217/168  |  提交时间：2018/05/25
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17305/7526  |  提交时间：2018/07/04
Discovery of 4-Methyl-N-(44(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-y1)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 1, 页码: 273-289
作者:  Wang, Qiang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Qi, Ziping;  Chen, Cheng;  Yu, Kailin;  Hu, Chen;  Qi, Shuang;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Wang, Wei;  Wang, Li;  Liang, Qianmao;  Zhang, Shanchun;  Ren, Tao;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(3516Kb)  |  收藏  |  浏览/下载：108/59  |  提交时间：2018/07/04
Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy 期刊论文
THERANOSTICS, 2017, 卷号: 7, 期号: 18, 页码: 4605-4617
作者:  Wang, Dongdong;  Zhou, Jiajia;  Shi, Ruohong;  Wu, Huihui;  Chen, Ruhui;  Duan, Beichen;  Xia, Guoliang;  Xu, Pengping;  Wang, Hui;  Zhou, Shu;  Wang, Chengming;  Wang, Haibao;  Guo, Zhen;  Chen, Qianwang
浏览  |  Adobe PDF(4494Kb)  |  收藏  |  浏览/下载：93/39  |  提交时间：2019/06/17
MOFs  photothermal  chemotherapy  pH-responsive  NIR-responsive  
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 11, 页码: 18359-18372
作者:  Hu, Chen;  Wang, Aoli;  Wu, Hong;  Qi, Ziping;  Li, Xixiang;  Yan, Xiao-E;  Chen, Cheng;  Yu, Kailin;  Zou, Fengming;  Wang, Wenchao;  Wang, Wei;  Wu, Jiaxin;  Liu, Juan;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6153Kb)  |  收藏  |  浏览/下载：184/48  |  提交时间：2018/07/04
Egfr  Egfrt790m  Nsclc  Kinase Inhibitors  Drug Resistance  
Rutin ameliorates obesity through brown fat activation 期刊论文
FASEB JOURNAL, 2017, 卷号: 31, 期号: 1, 页码: 333-+
作者:  Yuan, Xiaoxue;  Wei, Gang;  You, Yilin;  Huang, Yuanyuan;  Lee, Hyuek Jong;  Dong, Meng;  Lin, Jun;  Hu, Tao;  Zhang, Hanlin;  Zhang, Chuanhai;  Zhou, Huiqiao;  Ye, Rongcai;  Qi, Xiaolong;  Zhai, Baiqiang;  Huang, Weidong;  Liu, Shunai;  Xie, Wen;  Liu, Qingsong;  Liu, Xiaomeng;  Cui, Chengbi;  Li, Donghao;  Zhan, Jicheng;  Cheng, Jun;  Yuan, Zengqiang;  Jin, Wanzhu
浏览  |  Adobe PDF(2063Kb)  |  收藏  |  浏览/下载：166/45  |  提交时间：2018/07/04
Brown Adipose Tissue  Rutin  Obesity  Energy Expenditure  Mitochondria