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Tailoring Surface Opening of Hollow Nanocubes and Their Application as Nanocargo Carriers 期刊论文
ACS CENTRAL SCIENCE, 2018, 卷号: 4, 期号: 12, 页码: 1742-1750
作者:  Lu, Fang;  Xin, Huolin;  Xia, Weiwei;  Liu, Mingzhao;  Zhang, Yugang;  Cai, Weiping;  Gang, Oleg
浏览  |  Adobe PDF(5827Kb)  |  收藏  |  浏览/下载：60/24  |  提交时间：2020/03/31
NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy 期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2018, 卷号: 6, 期号: 47, 页码: 7794-7799
作者:  Nie, Rongrong;  Liu, Hongji;  Hu, Lin;  Gu, Xinyu;  Qian, Junchao;  Wang, Hui
收藏  |  浏览/下载：31/0  |  提交时间：2019/12/25
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：196/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：29/0  |  提交时间：2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia  
Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy 期刊论文
MOLECULAR THERAPY, 2018, 卷号: 26, 期号: 10, 页码: 2456-2465
作者:  Sun, Yuxiang;  Dai, Hui;  Chen, Shaopeng;  Zhang, Yajun;  Wu, Tao;  Cao, Xianbin;  Zhao, Guoping;  Xu, An;  Wang, Jun;  Wu, Lijun
收藏  |  浏览/下载：30/0  |  提交时间：2019/12/25
Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy 期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2018, 卷号: 10, 期号: 37, 页码: 31114-31123
作者:  Wang, Dan;  Lin, Haiyan;  Zhang, Guilong;  Si, Yuanchun;  Yang, Hongyi;  Bai, Guo;  Yang, Chi;  Zhong, Kai;  Cai, Dongqing;  Wu, Zhengyan;  Wang, Renfei;  Zou, Duohong
收藏  |  浏览/下载：64/0  |  提交时间：2019/12/20
pH-activated  synchronous  MRI  theranostic platform  tumor chemotherapy  
Carbon-based hybrid nanogels: a synergistic nanoplatform for combined biosensing, bioimaging, and responsive drug delivery 期刊论文
CHEMICAL SOCIETY REVIEWS, 2018, 卷号: 47, 期号: 11, 页码: 4198-4232
作者:  Wang, Hui;  Chen, Qianwang;  Zhou, Shuiqin
浏览  |  Adobe PDF(6297Kb)  |  收藏  |  浏览/下载：106/27  |  提交时间：2019/11/12
In Situ One-Pot Synthesis of MOF-Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy 期刊论文
ADVANCED SCIENCE, 2018, 卷号: 5, 期号: 6, 页码: 8
作者:  Wang, Dongdong;  Wu, Huihui;  Zhou, Jiajia;  Xu, Pengping;  Wang, Changlai;  Shi, Ruohong;  Wang, Haibao;  Wang, Hui;  Guo, Zhen;  Chen, Qianwang
收藏  |  浏览/下载：43/0  |  提交时间：2019/11/11
cancer theranostics  metal-organic framework-polymer  multimodal imaging  nanogels  photothermal effects  
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
浏览  |  Adobe PDF(6587Kb)  |  收藏  |  浏览/下载：151/107  |  提交时间：2019/08/23
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：596/506  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL