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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：195/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells 期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 658, 页码: 54-65
作者:  Ma, Jie;  Yu, K. N.;  Cheng, Cheng;  Ni, Guohua;  Shen, Jie;  Han, Wei
Adobe PDF(4120Kb)  |  收藏  |  浏览/下载：97/44  |  提交时间：2019/01/11
Non-thermal plasma  Reactive oxygen species  Heme oxygenase-1  Apoptotic death  c-JUN N-terminal kinase  
Conformational sensitivity of surface selection rules for quantitative Raman identification of small molecules in biofluids 期刊论文
NANOSCALE, 2018, 卷号: 10, 期号: 29, 页码: 14342-14351
作者:  Li, Lei;  Wang, Chao;  Yang, Lina;  Su, Mengke;  Yu, Fanfan;  Tian, Li;  Liu, Honglin
浏览  |  Adobe PDF(3734Kb)  |  收藏  |  浏览/下载：61/22  |  提交时间：2019/12/10
N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes 期刊论文
CHEMOSPHERE, 2018, 卷号: 204, 期号: 无, 页码: 463-473
作者:  Zhao, Sujuan;  Liu, Ying;  Wang, Fang;  Xu, Dexiang;  Xie, Ping
浏览  |  Adobe PDF(4185Kb)  |  收藏  |  浏览/下载：67/30  |  提交时间：2019/08/23
Microcystin  Endoplasmic reticulum stress  Apoptosis  N-acetylcysteine (NAC)  Zebrafish testes  
Magnetically-focusing biochip structures for high-speed active biosensing with improved selectivity 期刊论文
NANOTECHNOLOGY, 2018, 卷号: 29, 期号: 26, 页码: 11
作者:  Yoo, Haneul;  Lee, Dong Jun;  Kim, Daesan;  Park, Juhun;  Chen, Xing;  Hong, Seunghun
浏览  |  Adobe PDF(2339Kb)  |  收藏  |  浏览/下载：100/46  |  提交时间：2019/08/23
magnetic trap-and-release  magnetic nanobead  high speed immunoassay  biosensor  magnetically-focusing  
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
浏览  |  Adobe PDF(6587Kb)  |  收藏  |  浏览/下载：151/107  |  提交时间：2019/08/23
Screening oligonucleotide sequences for silver staining and D-galactose visual detection using RCA silver staining in a tube 期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 5, 页码: 507-515
作者:  Chen, Ziwei;  Duan, Xuying;  Wei, Hua;  Tang, Suming;  Xu, Chidong;  Li, Yanlei;  Guan, Yifu;  Zhao, Guojie
浏览  |  Adobe PDF(861Kb)  |  收藏  |  浏览/下载：119/39  |  提交时间：2019/06/03
galactose assay  rolling circle amplification  repressor  silver staining  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：596/506  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation 期刊论文
Advanced Science, 2018
作者:  Fu, Xuekun;  Li, Yunyan;  Huang,Tongling;  Yu, Zhiwu;  Ma, Kun;  Yang, Meng;  Liu, Qingli;  Pan, Haobo;  Wang, Huaiyu;  Wang, Junfeng;  Guan, Min
浏览  |  Adobe PDF(3502Kb)  |  收藏  |  浏览/下载：117/54  |  提交时间：2020/10/22
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibi 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018
作者:  Qiang Wang;  Feiyang Liu;  Qi S(亓爽);  Ziping Qi;  Beilei Wang;  Aoli Wang;  Zongru Jiang;  Wenchao Wang;  Qingsong Liu;  Jing Liu
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：132/54  |  提交时间：2020/10/20