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HFCAS OpenIR
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Discovery of 4-Methyl-N-(44(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-y1)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 1, 页码: 273-289
作者:  Wang, Qiang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Qi, Ziping;  Chen, Cheng;  Yu, Kailin;  Hu, Chen;  Qi, Shuang;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Wang, Wei;  Wang, Li;  Liang, Qianmao;  Zhang, Shanchun;  Ren, Tao;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(3516Kb)  |  收藏  |  浏览/下载：107/58  |  提交时间：2018/07/04
Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 18, 页码: 8456-8472
作者:  Li, Binhua;  Wang, Aoli;  Liu, Juan;  Qi, Ziping;  Liu, Xiaochuan;  Yu, Kailin;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Wang, Wenchao;  Wu, Jiaxin;  Hu, Zhenquan;  Ye, Ling;  Zou, Fengming;  Liu, Feiyang;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shaojuan;  Bai, Mingfeng;  Zhang, Shanchun;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(2856Kb)  |  收藏  |  浏览/下载：1410/1299  |  提交时间：2017/11/21