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HFCAS OpenIR
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Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
浏览  |  Adobe PDF(13868Kb)  |  收藏  |  浏览/下载：378/323  |  提交时间：2020/05/21
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：198/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
浏览  |  Adobe PDF(6587Kb)  |  收藏  |  浏览/下载：153/108  |  提交时间：2019/08/23
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：598/506  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders 期刊论文
JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 卷号: 214, 期号: 11, 页码: 3219-3238
作者:  Jiang, Hua;  He, Hongbin;  Chen, Yun;  Huang, Wei;  Cheng, Jinbo;  Ye, Jin;  Wang, Aoli;  Tao, Jinhui;  Wang, Chao;  Liu, Qingsong;  Jin, Tengchuan;  Jiang, Wei;  Deng, Xianming;  Zhou, Rongbin
浏览  |  Adobe PDF(2740Kb)  |  收藏  |  浏览/下载：232/160  |  提交时间：2019/06/17
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：86/31  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21284/11467  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-10
作者:  Wu, Hong;  Huang, Qiong;  Qi, Ziping;  Chen, Yongfei;  Wang, Aoli;  Chen, Cheng;  Liang, Qianmao;  Wang, Jinghua;  Chen, Wensheng;  Dong, Jin;  Yu, Kailin;  Hu, Chen;  Wang, Wenchao;  Liu, Xiaochuan;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Li, Xiaoxiang;  Gray, Nathanael S.;  Liu, Jing;  Wei, Wei;  Liu, Qingsong
浏览  |  Adobe PDF(3966Kb)  |  收藏  |  浏览/下载：132/67  |  提交时间：2018/07/04
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 11, 页码: 18359-18372
作者:  Hu, Chen;  Wang, Aoli;  Wu, Hong;  Qi, Ziping;  Li, Xixiang;  Yan, Xiao-E;  Chen, Cheng;  Yu, Kailin;  Zou, Fengming;  Wang, Wenchao;  Wang, Wei;  Wu, Jiaxin;  Liu, Juan;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6153Kb)  |  收藏  |  浏览/下载：184/48  |  提交时间：2018/07/04
Egfr  Egfrt790m  Nsclc  Kinase Inhibitors  Drug Resistance  
Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 43, 页码: 69760-69769
作者:  Wang, Aoli;  Yan, Xiao-E;  Wu, Hong;  Wang, Wenchao;  Hu, Chen;  Chen, Cheng;  Zhao, Zheng;  Zhao, Peng;  Li, Xixiang;  Wang, Li;  Wang, Beilei;  Ye, Zi;  Wang, Jinhua;  Wang, Chu;  Zhang, Wei;  Gray, Nathanael S.;  Weisberg, Ellen L.;  Chen, Liang;  Liu, Jing;  Yun, Cai-Hong;  Liu, Qingsong
浏览  |  Adobe PDF(2026Kb)  |  收藏  |  浏览/下载：127/65  |  提交时间：2017/11/21
Ibrutinib  Egfr Kinase  Dfg-in/c-helix-out  Inactive Conformation  Nsclc