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HFCAS OpenIR
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Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：86/31  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21284/11467  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-10
作者:  Wu, Hong;  Huang, Qiong;  Qi, Ziping;  Chen, Yongfei;  Wang, Aoli;  Chen, Cheng;  Liang, Qianmao;  Wang, Jinghua;  Chen, Wensheng;  Dong, Jin;  Yu, Kailin;  Hu, Chen;  Wang, Wenchao;  Liu, Xiaochuan;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Li, Xiaoxiang;  Gray, Nathanael S.;  Liu, Jing;  Wei, Wei;  Liu, Qingsong
浏览  |  Adobe PDF(3966Kb)  |  收藏  |  浏览/下载：132/67  |  提交时间：2018/07/04
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 11, 页码: 18359-18372
作者:  Hu, Chen;  Wang, Aoli;  Wu, Hong;  Qi, Ziping;  Li, Xixiang;  Yan, Xiao-E;  Chen, Cheng;  Yu, Kailin;  Zou, Fengming;  Wang, Wenchao;  Wang, Wei;  Wu, Jiaxin;  Liu, Juan;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6153Kb)  |  收藏  |  浏览/下载：184/48  |  提交时间：2018/07/04
Egfr  Egfrt790m  Nsclc  Kinase Inhibitors  Drug Resistance  
Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML) 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 29, 页码: 45562-45574
作者:  Liu, Feiyang;  Wang, Beilei;  Wang, Qiang;  Qi, Ziping;  Chen, Cheng;  Kong, Lu-Lu;  Chen, Ji-Yun;  Liu, Xiaochuan;  Wang, Aoli;  Hu, Chen;  Wang, Wenchao;  Wang, Huiping;  Wu, Fan;  Ruan, Yanjie;  Qi, Shuang;  Liu, Juan;  Zou, Fengming;  Hu, Zhenquan;  Wang, Wei;  Wang, Li;  Zhang, Shanchun;  Yun, Cai-Hong;  Zhai, Zhimin;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(8054Kb)  |  收藏  |  浏览/下载：256/202  |  提交时间：2017/11/21
Bcr-abl  Pdgfr  Chronic Myeloid Leukemia  Kinase Inhibitor  
Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 20, 页码: 29131-29142
作者:  Wang, Aoli;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Qi, Ziping;  Wang, Wenchao;  Yu, Kailin;  Liu, Xiaochuan;  Zou, Fengming;  Zhao, Zheng;  Wu, Jiaxin;  Liu, Juan;  Liu, Feiyang;  Wang, Li;  Stone, Richard M.;  Galinksy, Ilene A.;  Griffin, James D.;  Zhang, Shanchun;  Weisberg, Ellen L.;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(4786Kb)  |  收藏  |  浏览/下载：135/35  |  提交时间：2017/11/16
Acute Myeloid Leukemia  Flt3-itd  Akt  A6745763  Flt3-ligand  
Discovery of N-(34(1-lsonicotinoylpiperidin-4-yl)oxy)-4methylpheny1)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 8, 页码: 3964-3979
作者:  Wang, Qang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Chen, Cheng;  Liu, Xiaochuan;  Wang, Aoli;  Qi, Shuang;  Wang, Wenchao;  Qi, Ziping;  Zhao, Zheng;  Hu, Zhenquan;  Wang, Wei;  Wang, Li;  Zhang, Shanchun;  Wang, Yuexiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10221Kb)  |  收藏  |  浏览/下载：130/76  |  提交时间：2017/11/10
Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 5, 页码: 1984-2004
作者:  Liang, Xiaofei;  Liu, Xiaochuan;  Wang, Beilei;  Zou, Fengming;  Wang, Aoli;  Qi, Shuan;  Chen, Cheng;  Zhao, Zheng;  Wang, Wenchao;  Qi, Ziping;  Lv, Fengchao;  Hu, Zhenquan;  Wang, Li;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(3635Kb)  |  收藏  |  浏览/下载：13711/5312  |  提交时间：2017/11/06
Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 24, 页码: 9625-9638
作者:  Li, Xixiang;  Wang, Aoli;  Yu, Kailin;  Qi, Ziping;  Chen, Cheng;  Wang, Wenchao;  Hu, Chen;  Wu, Hong;  Wu, Jiaxin;  Zhao, Zheng;  Liu, Juan;  Zou, Fengming;  Wang, Li;  Wang, Beilei;  Wang, Wei;  Zhang, Shanchun;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6123Kb)  |  收藏  |  浏览/下载：161/100  |  提交时间：2017/10/25