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Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 1, 页码: 52-64
作者:  Deng, Ke;  Shen, Jiawei;  Wang, Wei;  Li, Ming;  Li, Hong;  Chen, Cheng;  Zhao, Huan;  Zhang, Mei;  Xue, Tian;  Liu, Qingsong;  Lui, Vivian Wai Yan;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(3554Kb)  |  收藏  |  浏览/下载：71/28  |  提交时间：2020/03/31
small cell lung cancer  digoxin  NaCl  cardiac glycosides  ATP1A1  
The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China 期刊论文
CANCER MANAGEMENT AND RESEARCH, 2019, 卷号: 11, 期号: 无, 页码: 1473-1492
作者:  Wu, Haibo;  Wang, Wei;  Du, Jun;  Li, Hong;  Wang, Huogang;  Huang, Liangliang;  Xiang, Hang;  Xie, Jing;  Liu, Xiaoli;  Li, Heng;  Lin, Wenchu
浏览  |  Adobe PDF(1845Kb)  |  收藏  |  浏览/下载：194/161  |  提交时间：2020/05/21
breast cancer  PIK3CA  clinicopathological characteristics  prognosis  
Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report 期刊论文
MEDICINE, 2018, 卷号: 97, 期号: 20, 页码: 4
作者:  Liao, Jia-Ming;  Wang, Wei;  Xie, Jing;  Wu, Hai-Bo
浏览  |  Adobe PDF(530Kb)  |  收藏  |  浏览/下载：71/29  |  提交时间：2019/08/26
dysembryoplastic neuroepithelial tumor  fluorescence in situ hybridisation  KIAA1549-BRAF fusion gene  pilocytic astrocytoma  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：84/31  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21281/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 11, 页码: 18359-18372
作者:  Hu, Chen;  Wang, Aoli;  Wu, Hong;  Qi, Ziping;  Li, Xixiang;  Yan, Xiao-E;  Chen, Cheng;  Yu, Kailin;  Zou, Fengming;  Wang, Wenchao;  Wang, Wei;  Wu, Jiaxin;  Liu, Juan;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6153Kb)  |  收藏  |  浏览/下载：183/48  |  提交时间：2018/07/04
Egfr  Egfrt790m  Nsclc  Kinase Inhibitors  Drug Resistance  
Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML 期刊论文
LEUKEMIA, 2016, 卷号: 30, 期号: 10, 页码: 2112-2116
作者:  Wu, H.;  Wang, A.;  Qi, Z.;  Li, X.;  Chen, C.;  Yu, K.;  Zou, F.;  Hu, C.;  Wang, W.;  Zhao, Z.;  Wu, J.;  Liu, J.;  Liu, X.;  Wang, L.;  Wang, W.;  Zhang, S.;  Stone, R. M.;  Galinsky, I. A.;  Griffin, J. D.;  Weinstock, D.;  Christodoulou, A.;  Wang, H.;  Shen, Y.;  Zhai, Z.;  Weisberg, E. L.;  Liu, J.;  Liu, Q.
浏览  |  Adobe PDF(1142Kb)  |  收藏  |  浏览/下载：111/71  |  提交时间：2017/11/21
Peptide-Assisted Enhancement of Inhibitory Effects of Small Molecular Inhibitors for Kinases 期刊论文
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2016, 卷号: 89, 期号: 4, 页码: 444-446
作者:  Wang, Wei;  Hirano, Yoshinori;  Uzawa, Takanori;  Taiji, Makoto;  Ito, Yoshihiro
浏览  |  Adobe PDF(1917Kb)  |  收藏  |  浏览/下载：96/44  |  提交时间：2017/11/10
Ibrutinib selectively targets FLT3-ITD in mutant FLT3-positive AML 期刊论文
LEUKEMIA, 2016, 卷号: 30, 期号: 3, 页码: 754-757
作者:  Wu, H.;  Hu, C.;  Wang, A.;  Weisberg, E. L.;  Wang, W.;  Chen, C.;  Zhao, Z.;  Yu, K.;  Liu, J.;  Wu, J.;  Nonami, A.;  Wang, L.;  Wang, B.;  Stone, R. M.;  Liu, S.;  Griffin, J. D.;  Liu, J.;  Liu, Q.
浏览  |  Adobe PDF(422Kb)  |  收藏  |  浏览/下载：140/79  |  提交时间：2017/11/06