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中国科学院合肥物质科学研究院机构知识库
Knowledge Management System of Hefei Institute of Physical Science,CAS
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CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Cao, Jiang-yan
;
Qi, Shuang
;
Wu, Hong
;
Wang, Ao-li
;
Liu, Qing-wang
;
Li, Xi-xiang
;
Wang, Bei-lei
;
Ge, Juan
;
Zou, Feng-ming
;
Chen, Cheng
;
Wang, Jun-jie
;
Hu, Chen
;
Liu, Jing
;
Wang, Wen-chao
;
Liu, Qing-song
收藏
  |  
浏览/下载:104/0
  |  
提交时间:2022/03/28
HER2
breast cancers
gastric cancers
irreversible inhibitor
drug resistance
An overview of kinase downregulators and recent advances in discovery approaches
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:
Wang, Beilei
;
Wu, Hong
;
Hu, Chen
;
Wang, Haizhen
;
Liu, Jing
;
Wang, Wenchao
;
Liu, Qingsong
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2022/01/25
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:
Chen, Cheng
;
Cheng, Chuan-dong
;
Wu, Hong
;
Wang, Zuo-wei
;
Wang, Li
;
Jiang, Zong-ru
;
Wang, Ao-li
;
Hu, Chen
;
Dong, Yong-fei
;
Niu, Wan-xiang
;
Qi, Shuang
;
Qi, Zi-ping
;
Liu, Jing
;
Wang, Wen-chao
;
Niu, Chao-shi
;
Liu, Qing-song
浏览
  |  
Adobe PDF(3476Kb)
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  |  
浏览/下载:101/36
  |  
提交时间:2020/11/26
glioblastoma
osimertinib
temozolamide
MAPK-signaling pathway
MNK
eukaryotic translation initiation factor 4E
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML)
期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:
Wu, Jiaxin
;
Wang, Aoli
;
Li, Xixiang
;
Chen, Cheng
;
Qi, Ziping
;
Hu, Chen
;
Wang, Wenliang
;
Wu, Hong
;
Huang, Tao
;
Zhao, Ming
;
Wang, Wenchao
;
Hu, Zhenquan
;
Liu, Qingwang
;
Wang, Beilei
;
Wang, Li
;
Li, Lili
;
Ge, Jian
;
Ren, Tao
;
Xia, Ruixiang
;
Liu, Jing
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/11/27
BCR-ABL
PDGFR
chronic myeloid leukemia
kinase inhibitor
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models
期刊论文
CANCER LETTERS, 2019, 页码: 105-114
作者:
Lu, Tingting
;
Chen, Cheng
;
Wang, Aoli
;
Jiang, Zongru
;
Qi, Ziping
;
Hu, Zhenquan
;
Hu, Chen
;
Liu, Feiyang
;
Wang, Wenliang
;
Wu, Hong
;
Wang, Beilei
;
Wang, Li
;
Qi, Shuang
;
Wu, Jiaxin
;
Wang, Wenchao
;
Tang, Jun
;
Yan, Hezhong
;
Bai, Mingfeng
;
Liu, Qingsong
;
Liu, Jing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/14
cKIT T670I mutant
Activation loop mutants
Drug resistance
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
;
Wu, Hong
;
Zhang, Yicong
;
Liu, Xiaochuan
;
Wang, Wenliang
;
Wang, Junjie
;
Hu, Zhenquan
;
Wang, Aoli
;
Huang, Tao
;
Liu, Qingwang
;
Wang, Wei
;
Wang, Li
;
Wang, Wenchao
;
Ren, Tao
;
Li, Lili
;
Xia, Ruixiang
;
Ge, Jian
;
Liu, Qingsong
;
Liu, Jing
Adobe PDF(4593Kb)
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收藏
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浏览/下载:195/104
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:
Wang, Beilei
;
Wu, Jiaxin
;
Wu, Yun
;
Chen, Cheng
;
Zou, Fengming
;
Wang, Aoli
;
Wu, Hong
;
Hu, Zhenquan
;
Jiang, Zongru
;
Liu, Qingwang
;
Wang, Wei
;
Zhang, Yicong
;
Liu, Feiyang
;
Zhao, Ming
;
Hu, Jie
;
Huang, Tao
;
Ge, Juan
;
Wang, Li
;
Ren, Tao
;
Wang, Yuxin
;
Liu, Jing
;
Liu, Qingsong
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/25
CDK9
Kinase inhibitor
Structure-activity relationship
Leukemia
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:
Wang, Aoli
;
Li, Xixiang
;
Chen, Cheng
;
Wu, Hong
;
Qi, Ziping
;
Hu, Chen
;
Yu, Kailin
;
Wu, Jiaxin
;
Liu, Juan
;
Liu, Xiaochuan
;
Hu, Zhenquan
;
Wang, Wei
;
Wang, Wenliang
;
Wang, Wenchao
;
Wang, Li
;
Wang, Beilei
;
Liu, Qingwang
;
Li, Lili
;
Ge, Jian
;
Ren, Tao
;
Zhang, Shanchun
;
Xia, Ruixiang
;
Liu, Jing
;
Liu, Qingsong
浏览
  |  
Adobe PDF(10028Kb)
  |  
收藏
  |  
浏览/下载:84/31
  |  
提交时间:2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:
Chen, Yongfei
;
Wu, Jiaxin
;
Wang, Aoli
;
Qi, Ziping
;
Jiang, Taoshan
;
Chen, Cheng
;
Zou, Fengming
;
Hu, Chen
;
Wang, Wei
;
Wu, Hong
;
Hu, Zhenquan
;
Wang, Wenchao
;
Wang, Beilei
;
Wang, Li
;
Ren, Tao
;
Zhang, Shanchun
;
Liu, Qingsong
;
Liu, Jing
浏览
  |  
Adobe PDF(12656Kb)
  |  
收藏
  |  
浏览/下载:21281/11466
  |  
提交时间:2018/08/17
Egfr
Alk
Dual Kinase Inhibitor
Non-small Cell Lung Cancer
Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis
期刊论文
PHYTOTHERAPY RESEARCH, 2017, 卷号: 31, 期号: 4, 页码: 631-637
作者:
Wang, Rong
;
Wu, Hong
;
Chen, Jian
;
Li, Shu-Ping
;
Dai, Li
;
Zhang, Zheng-Rong
;
Wang, Wen-Yu
浏览
  |  
Adobe PDF(505Kb)
  |  
收藏
  |  
浏览/下载:301/242
  |  
提交时间:2018/05/17
Geniposide
Mesenteric Lymph Node Lymphocytes
Inflammation
Erk1/2 Signaling Pathway