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HFCAS OpenIR
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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy 期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:  Hua, Chen;  Shena, Lijuan;  Zoua, Fengming;  Wua, Yun;  Wanga, Beilei;  Wanga, Aoli;  Wud, Chao;  Wanga, Li;  Liua, Jing;  Wanga, Wenchao;  Liua, Qingsong
收藏  |  浏览/下载：39/0  |  提交时间：2023/11/10
Acquired resistance mutations  CDK9 inhibitors  Transcription  Single nucleotide polymorphisms  BAY1251152  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：84/31  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21281/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-10
作者:  Wu, Hong;  Huang, Qiong;  Qi, Ziping;  Chen, Yongfei;  Wang, Aoli;  Chen, Cheng;  Liang, Qianmao;  Wang, Jinghua;  Chen, Wensheng;  Dong, Jin;  Yu, Kailin;  Hu, Chen;  Wang, Wenchao;  Liu, Xiaochuan;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Li, Xiaoxiang;  Gray, Nathanael S.;  Liu, Jing;  Wei, Wei;  Liu, Qingsong
浏览  |  Adobe PDF(3966Kb)  |  收藏  |  浏览/下载：130/67  |  提交时间：2018/07/04
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 11, 页码: 18359-18372
作者:  Hu, Chen;  Wang, Aoli;  Wu, Hong;  Qi, Ziping;  Li, Xixiang;  Yan, Xiao-E;  Chen, Cheng;  Yu, Kailin;  Zou, Fengming;  Wang, Wenchao;  Wang, Wei;  Wu, Jiaxin;  Liu, Juan;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6153Kb)  |  收藏  |  浏览/下载：183/48  |  提交时间：2018/07/04
Egfr  Egfrt790m  Nsclc  Kinase Inhibitors  Drug Resistance  
Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 22, 页码: 32641-32651
作者:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Chen, Cheng;  Liu, Juanjuan;  Zhao, Zheng;  Wu, Hong;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Wu, Jiaxin;  Liu, Feiyang;  Fernandes, Stacey M.;  Adamia, Sophia;  Stone, Richard M.;  Galinsky, Ilene A.;  Brown, Jennifer R.;  Griffin, James D.;  Zhang, Shanchun;  Loh, Teckpeng;  Zhang, Xin;  Wang, Wenchao;  Weisberg, Ellen L.;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(5138Kb)  |  收藏  |  浏览/下载：84/29  |  提交时间：2017/11/16
Pi3k Delta  Leukemia  B-cell Malignances  Pi3k  Kinase Inhibitors  
Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 5, 页码: 1984-2004
作者:  Liang, Xiaofei;  Liu, Xiaochuan;  Wang, Beilei;  Zou, Fengming;  Wang, Aoli;  Qi, Shuan;  Chen, Cheng;  Zhao, Zheng;  Wang, Wenchao;  Qi, Ziping;  Lv, Fengchao;  Hu, Zhenquan;  Wang, Li;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(3635Kb)  |  收藏  |  浏览/下载：13708/5311  |  提交时间：2017/11/06
1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells 期刊论文
SCIENCE BULLETIN, 2015, 卷号: 60, 期号: 24, 页码: 2120-2128
作者:  Zhang, Lei;  Yang, Xingxing;  Liu, Juanjuan;  Luo, Yan;  Li, Zhiyuan;  Ji, Xinmiao;  Wang, Wenchao;  Zhang, Xin
浏览  |  Adobe PDF(627Kb)  |  收藏  |  浏览/下载：88/38  |  提交时间：2017/10/25
Static Magnetic Field  Cell Proliferation  Mtor  Mtor Inhibitor  Feedback Reactivation  
1T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells 期刊论文
Sci. Bull., 2015, 卷号: 60, 期号: 24, 页码: 2120-2128
作者:  Lei Zhang;  Xingxing Yang;  Juanjuan Liu;  Yan Luo;  Zhiyuan Li;  Xinmiao Ji;  Wenchao Wang;  Xin Zhang
Adobe PDF(3399Kb)  |  收藏  |  浏览/下载：76/38  |  提交时间：2016/01/11
Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma 期刊论文
ACS Chem. Biol, 2014, 卷号: 9, 期号: 5, 页码: 1086-1091
作者:  Hong Wu;  Wenchao Wang;  Feiyang Liu;  Yongfei Chen;  Binhua Li;  Aoli Wang;  Beilei Wang;  Zheng Zhao;  Chen Hu;  Hong Li;  Jing Liu;  Qingsong Liu等
浏览  |  Adobe PDF(2079Kb)  |  收藏  |  浏览/下载：38/24  |  提交时间：2016/11/22