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Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
浏览  |  Adobe PDF(13868Kb)  |  收藏  |  浏览/下载：377/322  |  提交时间：2020/05/21
Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 1, 页码: 52-64
作者:  Deng, Ke;  Shen, Jiawei;  Wang, Wei;  Li, Ming;  Li, Hong;  Chen, Cheng;  Zhao, Huan;  Zhang, Mei;  Xue, Tian;  Liu, Qingsong;  Lui, Vivian Wai Yan;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(3554Kb)  |  收藏  |  浏览/下载：71/28  |  提交时间：2020/03/31
small cell lung cancer  digoxin  NaCl  cardiac glycosides  ATP1A1  
The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China 期刊论文
CANCER MANAGEMENT AND RESEARCH, 2019, 卷号: 11, 期号: 无, 页码: 1473-1492
作者:  Wu, Haibo;  Wang, Wei;  Du, Jun;  Li, Hong;  Wang, Huogang;  Huang, Liangliang;  Xiang, Hang;  Xie, Jing;  Liu, Xiaoli;  Li, Heng;  Lin, Wenchu
浏览  |  Adobe PDF(1845Kb)  |  收藏  |  浏览/下载：194/161  |  提交时间：2020/05/21
breast cancer  PIK3CA  clinicopathological characteristics  prognosis  
The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer 期刊论文
CANCER BIOMARKERS, 2019, 卷号: 24, 期号: 1, 页码: 51-59
作者:  Li, Hong;  Wang, Huogang;  Deng, Ke;  Han, Wei;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(5535Kb)  |  收藏  |  浏览/下载：85/36  |  提交时间：2020/05/21
Small cell lung cancer  Bcl-2  Bim  ABT-263  cisplatin  radiation  
NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy 期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2018, 卷号: 6, 期号: 47, 页码: 7794-7799
作者:  Nie, Rongrong;  Liu, Hongji;  Hu, Lin;  Gu, Xinyu;  Qian, Junchao;  Wang, Hui
收藏  |  浏览/下载：31/0  |  提交时间：2019/12/25
Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy 期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2018, 卷号: 10, 期号: 37, 页码: 31114-31123
作者:  Wang, Dan;  Lin, Haiyan;  Zhang, Guilong;  Si, Yuanchun;  Yang, Hongyi;  Bai, Guo;  Yang, Chi;  Zhong, Kai;  Cai, Dongqing;  Wu, Zhengyan;  Wang, Renfei;  Zou, Duohong
收藏  |  浏览/下载：64/0  |  提交时间：2019/12/20
pH-activated  synchronous  MRI  theranostic platform  tumor chemotherapy  
Carbon-based hybrid nanogels: a synergistic nanoplatform for combined biosensing, bioimaging, and responsive drug delivery 期刊论文
CHEMICAL SOCIETY REVIEWS, 2018, 卷号: 47, 期号: 11, 页码: 4198-4232
作者:  Wang, Hui;  Chen, Qianwang;  Zhou, Shuiqin
浏览  |  Adobe PDF(6297Kb)  |  收藏  |  浏览/下载：106/27  |  提交时间：2019/11/12
Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report 期刊论文
MEDICINE, 2018, 卷号: 97, 期号: 20, 页码: 4
作者:  Liao, Jia-Ming;  Wang, Wei;  Xie, Jing;  Wu, Hai-Bo
浏览  |  Adobe PDF(530Kb)  |  收藏  |  浏览/下载：71/29  |  提交时间：2019/08/26
dysembryoplastic neuroepithelial tumor  fluorescence in situ hybridisation  KIAA1549-BRAF fusion gene  pilocytic astrocytoma  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：596/506  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21281/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer