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Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21281/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Kinases Involved in Both Autophagy and Mitosis 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 卷号: 18, 期号: 9, 页码: 1-15
作者:  Li, Zhiyuan;  Zhang, Xin
浏览  |  Adobe PDF(277Kb)  |  收藏  |  浏览/下载：109/50  |  提交时间：2018/08/17
Kinases  Autophagy  Mitosis  Cyclin-dependent Kinases  Aurora  Polo-like Kinases  
基于FGF21结构的药物设计及配体与受体的相互作用研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  赵宏鑫
Adobe PDF(4641Kb)  |  收藏  |  浏览/下载：19/0  |  提交时间：2018/01/18
Brown adipose tissue transplantation ameliorates polycystic ovary syndrome 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 卷号: 113, 期号: 10, 页码: 2708-2713
作者:  Yuan, Xiaoxue;  Hu, Tao;  Zhao, Han;  Huang, Yuanyuan;  Ye, Rongcai;  Lin, Jun;  Zhang, Chuanhai;  Zhang, Hanlin;  Wei, Gang;  Zhou, Huiqiao;  Dong, Meng;  Zhao, Jun;  Wang, Haibin;  Liu, Qingsong;  Lee, Hyuek Jong;  Jin, Wanzhu;  Chen, Zi-Jiang
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Brown Adipose Tissue  Transplantation  Ameliorates  Pcos  Adiponectin  
Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase of a Potent and Selective DDR1 Receptor Tyrosine Kinase 期刊论文
ACS Chem. Biol., 2013, 卷号: 8, 页码: 2145-2150
作者:  Hyung-Gu Kim,Li Tan,Ellen L. Weisberg,Feiyang Liu, Peter Canning,Hwan Geun Choi, Scott A. Ezell,Hong Wu, Zheng Zhao, Jinhua Wang, Anna Mandinova,James D. Griffin, Alex N. Bullock, Qingsong Liu,,‡ Sam W. Lee, Nathanael S. Gray
Adobe PDF(5958Kb)  |  收藏  |  浏览/下载：243/93  |  提交时间：2014/07/30