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Is level of acetylation directly correlated to radiation sensitivity of cancer cell? 期刊论文
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2019, 卷号: 813, 期号: 无, 页码: 13-19
作者:  Zhang, Fengqiu;  Chen, Zhu;  Shao, Changsheng;  Huang, Qing
浏览  |  Adobe PDF(3552Kb)  |  收藏  |  浏览/下载：61/21  |  提交时间：2020/03/31
Acetylation  Radiosensitivity  HeLa cells  Histone deacetylase inhibitors (HDACis)  Trichostatin A (TSA)  
Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion 期刊论文
FASEB JOURNAL, 2018, 卷号: 32, 期号: 5, 页码: 2411-2421
作者:  Xin, Yanlong;  Zhao, Yan;  Zheng, Jiangge;  Zhou, Haizhen;  Zhang, Xuejun Cai;  Tian, Changlin;  Huang, Yihua
浏览  |  Adobe PDF(1647Kb)  |  收藏  |  浏览/下载：105/35  |  提交时间：2019/08/23
X-ray crystallography  YidC/Oxa1/Alb3  membrane protein insertase  membrane protein biogenesis  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：596/506  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：84/31  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21282/11467  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
高尔基体蛋白STK16和G蛋白GNG7在有丝分裂和膜转运中的功能研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  刘娟娟
Adobe PDF(6840Kb)  |  收藏  |  浏览/下载：53/3  |  提交时间：2018/01/18
SNX16 regulates E-cadherin recycling through the mechanism of coordinated membrane and cargo binding 期刊论文
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2017, 卷号: 46, 期号: 无, 页码: S163-S163
作者:  Jinxin, X.;  Leilei, Z.;  Chanjuan, W.;  Junfeng, W.;  Duanqing, P.;  Xiaodong, S.;  Jinsong, L.
浏览  |  Adobe PDF(6053Kb)  |  收藏  |  浏览/下载：80/42  |  提交时间：2019/02/28
STK16 regulates actin dynamics to control Golgi organization and cell cycle 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-17
作者:  Liu, Juanjuan;  Yang, Xingxing;  Li, Binhua;  Wang, Junjun;  Wang, Wenchao;  Liu, Jing;  Liu, Qingsong;  Zhang, Xin
浏览  |  Adobe PDF(3465Kb)  |  收藏  |  浏览/下载：100/49  |  提交时间：2018/07/04
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17302/7525  |  提交时间：2018/07/04
The Protein Neddylation Pathway in Trypanosoma brucei FUNCTIONAL CHARACTERIZATION AND SUBSTRATE IDENTIFICATION 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 3, 页码: 1081-+
作者:  Liao, Shanhui;  Hu, Huiqing;  Wang, Tao;  Tu, Xiaoming;  Li, Ziyin
浏览  |  Adobe PDF(2776Kb)  |  收藏  |  浏览/下载：104/58  |  提交时间：2018/07/04