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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
收藏  |  浏览/下载：58/0  |  提交时间：2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
浏览  |  Adobe PDF(13868Kb)  |  收藏  |  浏览/下载：377/322  |  提交时间：2020/05/21
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models 期刊论文
CANCER LETTERS, 2019, 页码: 105-114
作者:  Lu, Tingting;  Chen, Cheng;  Wang, Aoli;  Jiang, Zongru;  Qi, Ziping;  Hu, Zhenquan;  Hu, Chen;  Liu, Feiyang;  Wang, Wenliang;  Wu, Hong;  Wang, Beilei;  Wang, Li;  Qi, Shuang;  Wu, Jiaxin;  Wang, Wenchao;  Tang, Jun;  Yan, Hezhong;  Bai, Mingfeng;  Liu, Qingsong;  Liu, Jing
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/14
cKIT T670I mutant  Activation loop mutants  Drug resistance  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：195/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Probing the chiral anomaly by planar Hall effect in Dirac semimetal Cd3As2 nanoplates 期刊论文
PHYSICAL REVIEW B, 2018, 卷号: 98, 期号: 16, 页码: 5
作者:  Wu, Min;  Zheng, Guolin;  Chu, Weiwei;  Liu, Yequn;  Gao, Wenshuai;  Zhang, Hongwei;  Lu, Jianwei;  Han, Yuyan;  Zhou, Jianhui;  Ning, Wei;  Tian, Mingliang
收藏  |  浏览/下载：41/0  |  提交时间：2019/12/25
SiO2-protected shell mediated templating synthesis of Fe-N-doped carbon nanofibers and their enhanced oxygen reduction reaction performance 期刊论文
ENERGY & ENVIRONMENTAL SCIENCE, 2018, 卷号: 11, 期号: 8, 页码: 2208-2215
作者:  Hu, Bi-Cheng;  Wu, Zhen-Yu;  Chu, Sheng-Qi;  Zhu, Hong-Wu;  Liang, Hai-Wei;  Zhang, Jing;  Yu, Shu-Hong
收藏  |  浏览/下载：227/0  |  提交时间：2019/11/11
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：84/31  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21281/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
作者:  Wang, Beilei;  Deng, Yuanxin;  Chen, Yongfei;  Yu, Kailin;  Wang, Aoli;  Liang, Qianmao;  Wang, Wei;  Chen, Cheng;  Wu, Hong;  Hu, Chen;  Miao, Weili;  Hur, Wooyoung;  Wang, Wenchao;  Hu, Zhenquan;  Weisberg, Ellen L.;  Wang, Jinhua;  Ren, Tao;  Wang, Yinsheng;  Gray, Nathanael S.;  Liu, Qingsong;  Liu, Jing
收藏  |  浏览/下载：350/0  |  提交时间：2018/08/16
Btk  Kinase Inhibitor  Irreversible Inhibitor  Structure-activity Relationship  B-cell Lymphoma  
In-plane magnetic anisotropy of the Sr4Ru3O10 nanosheet probed by planar Hall effect 期刊论文
APPLIED PHYSICS LETTERS, 2017, 卷号: 111, 期号: 3, 页码: 1-4
作者:  Liu, Yan;  Yang, Jiyong;  Chu, Weiwei;  Du, Haifeng;  Ning, Wei;  Ling, Langsheng;  Tong, Wei;  Qu, Zhe;  Cao, Gang;  Zhang, Yuheng;  Tian, Mingliang
浏览  |  Adobe PDF(1059Kb)  |  收藏  |  浏览/下载：101/46  |  提交时间：2018/08/16