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HFCAS OpenIR

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Zanubrutinib monotherapy for relapsed or refractory non-germinal center diffuse large B-cell lymphoma 期刊论文
BLOOD ADVANCES, 2022, 卷号: 6
作者:  Yang, Haiyan;  Xiang, Bing;  Song, Yuqin;  Zhang, Huilai;  Zhao, Weili;  Zou, Dehui;  Lv, Fangfang;  Guo, Wei;  Liu, Aichun;  Li, Caixia;  Tan, Ziwen;  Liu, Yang;  Fu, Lina;  Guo, Haiyi;  Novotny, William;  Huang, Jane;  Li, Yufu
收藏  |  浏览/下载：40/0  |  提交时间：2022/12/23
Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes using ultra-high-performance liquid chromatography combined with high-resolution mass spectrometry 期刊论文
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2022, 卷号: 36
作者:  Zhang, Hongjian;  Hu, Zhen;  Zhang, Huiping;  Sun, Xiyan;  Yang, Jianming;  Yuan, Jie
收藏  |  浏览/下载：53/0  |  提交时间：2022/03/28
Bruton's tyrosine kinase inhibitors in primary central nervous system lymphoma-evaluation of anti-tumor efficacy and brain distribution 期刊论文
TRANSLATIONAL CANCER RESEARCH, 2021, 卷号: 10
作者:  Yu, Haifeng;  Kong, Haiying;  Li, Cong;  Dong, Xiaowu;  Wu, Yizhe;  Zhuang, Yuxin;  Han, Shuiyun;  Lei, Tao;  Yang, Haiyan
收藏  |  浏览/下载：59/0  |  提交时间：2021/08/31
Primary central nervous system lymphoma ( PCNSL)  Bruton's tyrosine kinase (BTK)  ibrutinib  zanubrutinib  tirabrutinib  
一种薄膜热收缩率的自动测量方法 专利
专利类型: 发明专利, 专利号: ZL201810462258.1, 申请日期: 2021-03-02,
发明人:  刘勇;  张龙;  花昌义;  李志刚;  王澍;  吴晓松;  贾琳;  卢春
收藏  |  浏览/下载：37/0  |  提交时间：2021/12/14
一种薄膜样品全自动裁切方法与装置 专利
专利类型: 发明专利, 专利号: ZL201910879174.2, 申请日期: 2021-03-02,
发明人:  花昌义;  李志刚;  叶超;  王善锋;  孙淼;  吴浩;  吴晓松;  张龙;  刘勇
收藏  |  浏览/下载：36/0  |  提交时间：2021/12/14
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
浏览  |  Adobe PDF(6587Kb)  |  收藏  |  浏览/下载：153/108  |  提交时间：2019/08/23
Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid leukemia: a case report 期刊论文
FRONTIERS OF MEDICINE, 2018, 卷号: 12
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收藏  |  浏览/下载：30/0  |  提交时间：2020/10/26
BCL-2 INHIBITOR  MIDOSTAURIN  CLASSIFICATION  DECITABINE  MECHANISMS  MUTATIONS  TARGETS  IDH  BTK  venetoclax  cytarabine  AML  leukemia  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：86/31  |  提交时间：2019/06/17
新型不可逆BTK激酶抑制剂的发现研究 学位论文
, 北京: 中国科学院研究生院, 2017
作者:  邓远欣
Adobe PDF(2196Kb)  |  收藏  |  浏览/下载：635/1  |  提交时间：2018/01/17
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
作者:  Wang, Beilei;  Deng, Yuanxin;  Chen, Yongfei;  Yu, Kailin;  Wang, Aoli;  Liang, Qianmao;  Wang, Wei;  Chen, Cheng;  Wu, Hong;  Hu, Chen;  Miao, Weili;  Hur, Wooyoung;  Wang, Wenchao;  Hu, Zhenquan;  Weisberg, Ellen L.;  Wang, Jinhua;  Ren, Tao;  Wang, Yinsheng;  Gray, Nathanael S.;  Liu, Qingsong;  Liu, Jing
收藏  |  浏览/下载：351/0  |  提交时间：2018/08/16
Btk  Kinase Inhibitor  Irreversible Inhibitor  Structure-activity Relationship  B-cell Lymphoma