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HFCAS OpenIR

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The effect of EGFR-TKIs on survival in advanced non-small-cell lung cancer with EGFR mutations: A real-world study 期刊论文
CANCER MEDICINE, 2022
作者:  Yu, Xiaoqing;  Si, Jinfei;  Wei, Jingwen;  Wang, Yanling;  Sun, Yan;  Jin, Jianan;  Zhang, Xiaoyan;  Ma, Tonghui;  Song, Zhengbo
收藏  |  浏览/下载：45/0  |  提交时间：2022/12/23
EGFR-TKIs  non-small cell lung cancer (NSCLC)  real-world study  survival outcome  
Impact of clinical and molecular features on efficacy and outcome of patients with non-small cell lung cancer receiving second-line osimertinib 期刊论文
BMC CANCER, 2022, 卷号: 22
作者:  Jin, Ying;  Lin, Chen;  Shi, Xun;  He, Qiong;  Yan, Junrong;  Yu, Xinmin;  Chen, Ming
收藏  |  浏览/下载：38/0  |  提交时间：2022/12/23
Clinical and molecular features  Efficacy and outcome  EGFR T790M mutation  Non-small-cell lung cancer  Osimertinib  
Efficacy and safety of anlotinib with and without EGFR-TKIs or immunotherapy in the treatment of elder patients with non-small-cell lung cancer: a retrospective study 期刊论文
BMC PULMONARY MEDICINE, 2022, 卷号: 22
作者:  Wang, Wenxian;  Shao, Lan;  Xu, Yibing;  Song, Zhengbo;  Lou, Guangyuan;  Zhang, Yiping;  Chen, Ming
收藏  |  浏览/下载：31/0  |  提交时间：2022/12/23
Non-small cell lung cancer  Prognosis  Angiogenesis  Tyrosine kinase inhibitors  
The genomic landscape of young and old lung cancer patients highlights age-dependent mutation frequencies and clinical actionability in young patients 期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2021
作者:  Cai, Lei;  Chen, Yong;  Tong, Xiaoling;  Wu, Xue;  Bao, Hua;  Shao, Yang;  Luo, Zhuang;  Wang, Xuming;  Cao, Yang
收藏  |  浏览/下载：74/0  |  提交时间：2021/06/15
EGFR  ERBB2  gene fusions  tyrosine kinase inhibitors  young lung cancer patients  
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21281/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Clinical characteristics and response to tyrosine kinase inhibitors of patients with non-small cell lung cancer harboring uncommon epidermal growth factor receptor mutations 期刊论文
CHINESE JOURNAL OF CANCER RESEARCH, 2017, 卷号: 29
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收藏  |  浏览/下载：33/0  |  提交时间：2020/10/26
EGFR MUTATIONS  GEFITINIB TREATMENT  1ST-LINE TREATMENT  OPEN-LABEL  RARE  MULTICENTER  ERLOTINIB  GENE  CHEMOTHERAPY  EFFICACY  Non-small cell lung cancer  EGFR  uncommon mutation  target therapy  
Efficacy of afatinib, an irreversible ErbB family blocker, in the treatment of intracerebral metastases of non-small cell lung cancer in mice 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38
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收藏  |  浏览/下载：30/0  |  提交时间：2020/10/26
BRAIN METASTASES  CEREBROSPINAL-FLUID  GEFITINIB  INHIBITORS  CARCINOMA  RADIATION  ERLOTINIB  afatinib  tyrosine kinase inhibitor  non-small cell lung cancer  brain metastasis  pharmacokinetic/pharmacodynamics  pEGFR  
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 11, 页码: 18359-18372
作者:  Hu, Chen;  Wang, Aoli;  Wu, Hong;  Qi, Ziping;  Li, Xixiang;  Yan, Xiao-E;  Chen, Cheng;  Yu, Kailin;  Zou, Fengming;  Wang, Wenchao;  Wang, Wei;  Wu, Jiaxin;  Liu, Juan;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6153Kb)  |  收藏  |  浏览/下载：183/48  |  提交时间：2018/07/04
Egfr  Egfrt790m  Nsclc  Kinase Inhibitors  Drug Resistance  
Cell type- and density-dependent effect of 1 T static magnetic field on cell proliferation 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 8, 页码: 13126-13141
作者:  Zhang, Lei;  Ji, Xinmiao;  Yang, Xingxing;  Zhang, Xin
浏览  |  Adobe PDF(8563Kb)  |  收藏  |  浏览/下载：88/34  |  提交时间：2018/07/04
Static Magnetic Field  Cancer Cell  Egfr  
Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 43, 页码: 69760-69769
作者:  Wang, Aoli;  Yan, Xiao-E;  Wu, Hong;  Wang, Wenchao;  Hu, Chen;  Chen, Cheng;  Zhao, Zheng;  Zhao, Peng;  Li, Xixiang;  Wang, Li;  Wang, Beilei;  Ye, Zi;  Wang, Jinhua;  Wang, Chu;  Zhang, Wei;  Gray, Nathanael S.;  Weisberg, Ellen L.;  Chen, Liang;  Liu, Jing;  Yun, Cai-Hong;  Liu, Qingsong
浏览  |  Adobe PDF(2026Kb)  |  收藏  |  浏览/下载：124/63  |  提交时间：2017/11/21
Ibrutinib  Egfr Kinase  Dfg-in/c-helix-out  Inactive Conformation  Nsclc