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HFCAS OpenIR

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Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:  Liang, Xiaofei;  Wang, Chun;  Wang, Beilei;  Liu, Juan;  Qi, Shuang;  Wang, Aoli;  Liu, Qingwang;  Deng, Maoqing;  Wang, Li;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：43/0  |  提交时间：2022/12/23
CSF1R inhibitor  Kinase inhibitor  Macrophage polarization  
Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:  Cao, Guo-Zhen;  Ma, Li-Ying;  Zhang, Zong-Hui;  Wang, Xiao-Lin;  Hua, Jing-Han;  Zhang, Jia-Hui;  Lv, Yang;  Zhang, Shao-Bo;  Ou, Jian;  Lin, Wen-Chu
收藏  |  浏览/下载：48/0  |  提交时间：2022/12/22
small-cell lung cancer  H3  3  PARP1  PARP inhibitor  darinaparsin  combination treatment  
Influence of Dehydroxymethylepoxyquinomicin on Radiosensitivity of Thyroid Carcinoma TPC-1 Cells 期刊论文
JOURNAL OF ONCOLOGY, 2022, 卷号: 2022
作者:  Liu, Jie;  Cai, Hu;  Yi, Heqing;  Li, Xin;  Peng, Yunsong;  Li, Linfa
收藏  |  浏览/下载：52/0  |  提交时间：2022/12/22
Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235
作者:  Qu, Bingxue;  Xu, Yongjin;  Lu, Yang;  Zhuang, Weihao;  Jin, Xinxin;  Shi, Qiuqiu;  Yan, Shike;  Guo, Yu;  Shen, Zheyuan;  Che, Jinxin;  Wu, Yize;  Tong, Lexian;  Dong, Xiaowu;  Yang, Haiyan
收藏  |  浏览/下载：31/0  |  提交时间：2022/12/23
XPO1  Multiple myeloma  MM.1S  N-phenylsulfonamide  Oral administration  
IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation 期刊论文
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2022, 卷号: 22
作者:  Xu, Yipeng;  Pachnikova, Gabriela;  Wang, He;  Wu, Yaoyao;  Przybilla, Dorothea;  Schaefer, Reinhold;  Chen, Zihao;  Zhu, Shaoxing;  Keilholz, Ulrich
收藏  |  浏览/下载：46/0  |  提交时间：2022/12/23
IC50  docetaxel  spheroids  drug testing  preclinical models  prostate cancer  2D clinical models  3D clinical models  cell culture  
Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:  Fu, Weitao;  Zhang, Minkui;  Liao, Jianing;  Tang, Qing;  Lei, Yixuan;  Gong, Zhou;  Shan, Luhu;  Duan, Mojie;  Chai, Xin;  Pang, Jinping;  Tang, Chun;  Wang, Xuwen;  Xu, Xiaohong;  Li, Dan;  Sheng, Rong;  Hou, Tingjun
收藏  |  浏览/下载：53/0  |  提交时间：2022/03/21
Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes Ovarian Cancer Cell Stemness and Malignancy Through the Notch3-Mediated Signaling 期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 卷号: 9
作者:  Ji, Zhaodong;  Tian, Wenjuan;  Gao, Wen;  Zang, Rongyu;  Wang, Huaying;  Yang, Gong
收藏  |  浏览/下载：57/0  |  提交时间：2021/08/30
IL-8  tumor stemness  epithelial ovarian cancer  cancer-associated ovarian fibroblasts  Notch3 signal pathway  
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML) 期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:  Lu, Tingting;  Cao, Jiangyan;  Zou, Fengming;  Li, Xixiang;  Wang, Aoli;  Wang, Wenliang;  Liang, Huamin;  Liu, Qingwang;  Hu, Chen;  Chen, Cheng;  Hu, Zhenquan;  Wang, Wenchao;  Li, Lili;  Ge, Jian;  Shen, Yang;  Ren, Tao;  Liu, Jing;  Xia, Ruixiang;  Liu, Qingsong
收藏  |  浏览/下载：81/0  |  提交时间：2021/04/26
BCR-ABL  ABL mutants  Chronic myeloid leukemia  Kinase inhibitor  Imatinib resistance  
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214
作者:  Xu, Biao;  Wang, Zhi-Peng;  Liu, Qingwang;  Yang, Xiaohong;  Li, Xuemin;  Huang, Ding;  Qiu, Yanfei;  Tam, Kin Yip;  Zhang, Shao-Lin;  He, Yun
收藏  |  浏览/下载：66/0  |  提交时间：2021/04/26
Pyruvate dehydrogenase kinase  Proliferation  Cancer metabolism  Structure-activity relationship  
Structure elucidation of a novel cyclic tripeptide from the marine-derived fungus Aspergillus ochraceopetaliformis DSW-2 期刊论文
NATURAL PRODUCT RESEARCH, 2020
作者:  Liao, Yanyan;  Hong, Xuan;  Yang, Jing;  Qin, Jiang-Jiang;  Zhang, Beibei;  Lin, Jianhui;  Shao, Zongze;  Wang, Weiyi
收藏  |  浏览/下载：48/0  |  提交时间：2021/03/15
Fungus  structural elucidation  tripeptide