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Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235
作者:  Qu, Bingxue;  Xu, Yongjin;  Lu, Yang;  Zhuang, Weihao;  Jin, Xinxin;  Shi, Qiuqiu;  Yan, Shike;  Guo, Yu;  Shen, Zheyuan;  Che, Jinxin;  Wu, Yize;  Tong, Lexian;  Dong, Xiaowu;  Yang, Haiyan
收藏  |  浏览/下载：31/0  |  提交时间：2022/12/23
XPO1  Multiple myeloma  MM.1S  N-phenylsulfonamide  Oral administration  
Nano-selenium attenuates mitochondrial-associated apoptosis via the PI3K/AKT pathway in nickel-induced hepatotoxicity in vivo and in vitro 期刊论文
ENVIRONMENTAL TOXICOLOGY, 2021
作者:  Wang, Caixia;  Gu, Zhangyu;  Gu, Xueyan;  Tan, Xinyue;  Wang, Shuang;  Zhang, Rui;  Li, Ruifen;  Sun, Mingkun;  Gui, Chunyan;  Li, Sheng;  Ye, Yixing;  Ma, Jianhua;  Su, Li;  Liang, Changhao
收藏  |  浏览/下载：46/0  |  提交时间：2021/11/01
hepatotoxicity  mitochondrial apoptosis  Nano-Se  nickel  PI3K-Akt pathway  
Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways 期刊论文
JOURNAL OF INFLAMMATION RESEARCH, 2021, 卷号: 14
作者:  Ying, Zhen-Hua;  Li, Hui-Min;  Yu, Wen-Ying;  Yu, Chen-Huan
收藏  |  浏览/下载：61/0  |  提交时间：2021/04/26
isoflavone  glycolysis  Warburg effect  PKM2  JAK/STATs  NF-kappa B  
An ultra-long circulating nanoparticle for reviving a highly selective BCR-ABL inhibitor in long-term effective and safe treatment of chronic myeloid leukemia 期刊论文
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 卷号: 29
作者:  Fu, Liyi;  Zou, Fengming;  Liu, Qingwang;  Wang, Beilei;  Wang, Junqing;  Liang, Huamin;  Liang, Xiaofei;  Liu, Jing;  Shi, Jinjun;  Liu, Qingsong
收藏  |  浏览/下载：43/0  |  提交时间：2020/11/30
Chronic myeloid leukemia  BCR-ABL  Long-circulating nanoparticle  Drug delivery  
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:  Wang, Wen-liang;  Jiang, Zong-ru;  Hu, Chen;  Chen, Cheng;  Hu, Zhen-quan;  Wang, Ao-li;  Wang, Li;  Liu, Jing;  Wang, Wen-chao;  Liu, Qing-song
收藏  |  浏览/下载：62/0  |  提交时间：2020/11/26
PGK1  NG52  kinase inhibitor  Warburg effect  glioma  
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:  Chen, Cheng;  Cheng, Chuan-dong;  Wu, Hong;  Wang, Zuo-wei;  Wang, Li;  Jiang, Zong-ru;  Wang, Ao-li;  Hu, Chen;  Dong, Yong-fei;  Niu, Wan-xiang;  Qi, Shuang;  Qi, Zi-ping;  Liu, Jing;  Wang, Wen-chao;  Niu, Chao-shi;  Liu, Qing-song
浏览  |  Adobe PDF(3476Kb)  |  收藏  |  浏览/下载：101/36  |  提交时间：2020/11/26
glioblastoma  osimertinib  temozolamide  MAPK-signaling pathway  MNK  eukaryotic translation initiation factor 4E  
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:  Liang, Xiaofei;  Jiang, Zongru;  Huang, Zhenghui;  Li, Feng;  Chen, Cheng;  Hu, Chen;  Wang, Wenliang;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Qi, Ziping;  Liu, Jing;  Jiang, Lubin;  Liu, Qingsong
收藏  |  浏览/下载：59/0  |  提交时间：2020/11/26
PI4K kinase  Kinase inhibitor  Malaria  Blood stage  Liver stage  
A Novel Microfluidic Device Integrated with Chitosan-Modified Capillaries for Rapid ZIKV Detection 期刊论文
Micromachines, 2020, 卷号: 11
作者:  朱灵( zhu ling)
浏览  |  Adobe PDF(3906Kb)  |  收藏  |  浏览/下载：196/46  |  提交时间：2020/11/19
in situ PCR  molecular diagnosis  microfluidic chip  POC device  ZIKV  
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma 期刊论文
JOURNAL OF CANCER, 2020, 卷号: 11
作者:  Zhu, Guanxia;  Li, Xia;  Li, Jiong;  Zhou, Wei;  Chen, Zhongjian;  Fan, Yun;  Jiang, Youhua;  Zhao, Yue;  Sun, Guogui;  Mao, Weimin
收藏  |  浏览/下载：100/0  |  提交时间：2020/11/30
esophageal squamous cell carcinoma  oral squamous cell carcinoma  arsenic trioxide  cyclin D1  PD-L1  CDK4/6  
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019
作者:  Yun Wu;  Beilei Wang;  Junjie Wang;  Qi S(亓爽);  Fengming Zou;  Ziping Qi;  Feiyang Liu;  Wenchao Wang;  Qingsong Liu;  Jing Liu
浏览  |  Adobe PDF(5207Kb)  |  收藏  |  浏览/下载：129/65  |  提交时间：2020/10/20