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Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors (vol 0, pg 1, 2022) 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:  Cao, Guo-zhen;  Ma, Li-ying;  Zhang, Zong-hui;  Wang, Xiao-lin;  Hua, Jing-han;  Zhang, Jia-hui;  Lv, Yang;  Zhang, Shao-bo;  Ou, Jian;  Lin, Wen-chu
收藏  |  浏览/下载：38/0  |  提交时间：2022/12/23
Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:  Cao, Guo-Zhen;  Ma, Li-Ying;  Zhang, Zong-Hui;  Wang, Xiao-Lin;  Hua, Jing-Han;  Zhang, Jia-Hui;  Lv, Yang;  Zhang, Shao-Bo;  Ou, Jian;  Lin, Wen-Chu
收藏  |  浏览/下载：48/0  |  提交时间：2022/12/22
small-cell lung cancer  H3  3  PARP1  PARP inhibitor  darinaparsin  combination treatment  
Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair 期刊论文
ADVANCED SCIENCE, 2022
作者:  Zhang, Ben;  Thorne, Rick Francis;  Zhang, Pengfei;  Wu, Mian;  Liu, Lianxin
收藏  |  浏览/下载：43/0  |  提交时间：2022/12/23
genomic stability  HMGB1  long non-coding RNAs  PARP inhibitors  Vanguard  
The MYC Paralog-PARP1 Axis as a Potential TherapeuticTarget in MYC Paralog-Activated Small Cell Lung Cancer 期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:  Bian, Xing;  Wang, Xiaolin;  Zhang, Qiuyan;  Ma, Liying;  Cao, Guozhen;  Xu, Ao;  Han, Jinhua;  Huang, Jun;  Lin, Wenchu
收藏  |  浏览/下载：49/0  |  提交时间：2020/11/30
small cell lung cancer  MYCparalog  PARP1  BET  DNA damage response  
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019
作者:  Yun Wu;  Beilei Wang;  Junjie Wang;  Qi S(亓爽);  Fengming Zou;  Ziping Qi;  Feiyang Liu;  Wenchao Wang;  Qingsong Liu;  Jing Liu
浏览  |  Adobe PDF(5207Kb)  |  收藏  |  浏览/下载：129/65  |  提交时间：2020/10/20
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
浏览  |  Adobe PDF(13868Kb)  |  收藏  |  浏览/下载：377/322  |  提交时间：2020/05/21
Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 1, 页码: 52-64
作者:  Deng, Ke;  Shen, Jiawei;  Wang, Wei;  Li, Ming;  Li, Hong;  Chen, Cheng;  Zhao, Huan;  Zhang, Mei;  Xue, Tian;  Liu, Qingsong;  Lui, Vivian Wai Yan;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(3554Kb)  |  收藏  |  浏览/下载：71/28  |  提交时间：2020/03/31
small cell lung cancer  digoxin  NaCl  cardiac glycosides  ATP1A1  
The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer 期刊论文
CANCER BIOMARKERS, 2019, 卷号: 24, 期号: 1, 页码: 51-59
作者:  Li, Hong;  Wang, Huogang;  Deng, Ke;  Han, Wei;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(5535Kb)  |  收藏  |  浏览/下载：85/36  |  提交时间：2020/05/21
Small cell lung cancer  Bcl-2  Bim  ABT-263  cisplatin  radiation  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：195/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells 期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 658, 页码: 54-65
作者:  Ma, Jie;  Yu, K. N.;  Cheng, Cheng;  Ni, Guohua;  Shen, Jie;  Han, Wei
Adobe PDF(4120Kb)  |  收藏  |  浏览/下载：97/44  |  提交时间：2019/01/11
Non-thermal plasma  Reactive oxygen species  Heme oxygenase-1  Apoptotic death  c-JUN N-terminal kinase