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HFCAS OpenIR

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Immune microenvironment features and efficacy of PD-1/PD-L1 blockade in non-small cell lung cancer patients with EGFR or HER2 exon 20 insertions 期刊论文
THORACIC CANCER, 2020
作者:  Chen, Kaiyan;  Pan, Guoqiang;  Cheng, Guoping;  Zhang, Fanrong;  Xu, Yanjun;  Huang, Zhiyu;  Fan, Yun
收藏  |  浏览/下载：62/0  |  提交时间：2020/12/28
EGFR  HER2  immunotherapy  NSCLC  PD‐  L1  
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019
作者:  Yun Wu;  Beilei Wang;  Junjie Wang;  Qi S(亓爽);  Fengming Zou;  Ziping Qi;  Feiyang Liu;  Wenchao Wang;  Qingsong Liu;  Jing Liu
浏览  |  Adobe PDF(5207Kb)  |  收藏  |  浏览/下载：129/65  |  提交时间：2020/10/20
Numerical and experimental analysis of a rectangular single-phase natural circulation loop with asymmetric heater position 期刊论文
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 2019, 卷号: 130, 期号: 无, 页码: 1343-1357
作者:  Seyyedi, S. M.;  Sahebi, N.;  Dogonchi, A. S.;  Hashemi-Tilehnoee, M.
浏览  |  Adobe PDF(3592Kb)  |  收藏  |  浏览/下载：93/30  |  提交时间：2020/03/31
Single-phase  Natural circulation  Asymmetric heater  Stability  Friction  Laminar flow  Transition and turbulent flow  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：596/506  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibi 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018
作者:  Qiang Wang;  Feiyang Liu;  Qi S(亓爽);  Ziping Qi;  Beilei Wang;  Aoli Wang;  Zongru Jiang;  Wenchao Wang;  Qingsong Liu;  Jing Liu
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：132/54  |  提交时间：2020/10/20
等离子体处理和纳米二氧化钛对硫丹生殖毒性的影响 学位论文
, 北京: 中国科学院研究生院, 2017
作者:  王大延
Adobe PDF(1424Kb)  |  收藏  |  浏览/下载：86/4  |  提交时间：2018/01/18
线虫辐射损伤信号空间转导与机制研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  黎青青
Adobe PDF(4045Kb)  |  收藏  |  浏览/下载：18/0  |  提交时间：2018/01/18
All-Fiber Configuration Laser Self-Mixing Doppler Velocimeter Based on Distributed Feedback Fiber Laser 期刊论文
SENSORS, 2016, 卷号: 16, 期号: 8, 页码: 1-10
作者:  Wu, Shuang;  Wang, Dehui;  Xiang, Rong;  Zhou, Junfeng;  Ma, Yangcheng;  Gui, Huaqiao;  Liu, Jianguo;  Wang, Huanqin;  Lu, Liang;  Yu, Benli
Adobe PDF(7658Kb)  |  收藏  |  浏览/下载：95/54  |  提交时间：2017/07/03
Self-mixing Effect  Dfb Fiber Laser  Laser Doppler Velocimeter (Ldv)  
精准农业变量施肥控制技术研究 学位论文
, 合肥: 中国科学技术大学, 2016
作者:  宿宁
Adobe PDF(10289Kb)  |  收藏  |  浏览/下载：48/2  |  提交时间：2018/01/18
Peptide toxins and small-molecule blockers of BK channels 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 56-66
作者:  Yu, Mu;  Liu, San-ling;  Sun, Pei-bei;  Pan, Hao;  Tian, Chang-lin;  Zhang, Long-hua
浏览  |  Adobe PDF(1302Kb)  |  收藏  |  浏览/下载：188/48  |  提交时间：2017/10/25
Bk Channel  Peptide Toxins  Scorpion Venom  Iberiotoxin  Small-molecule Blockers  Alkaloids