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Structural Determinants for Light-Dependent Membrane Binding of a Photoswitchable Polybasic Domain 期刊论文
ACS SYNTHETIC BIOLOGY, 2021, 卷号: 10
作者:  Li, Ling;  He, Lian;  Wu, Bo;  Yu, Chuandi;  Zhao, Hongxin;  Zhou, Yubin;  Wang, Junfeng;  Zhu, Lei
收藏  |  浏览/下载：62/0  |  提交时间：2021/04/26
polybasic domain  LOV2  optogenetics  NMR  PI(4,5)P-2  protein-lipid interaction  
Characterization of an alternative BAK-binding site for BH3 peptides 期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11
作者:  Ye, Kaiqin;  Meng, Wei X.;  Sun, Hongbin;  Wu, Bo;  Chen, Meng;  Pang, Yuan-Ping;  Gao, Jia;  Wang, Hongzhi;  Wang, Junfeng;  Kaufmann, Scott H.;  Dai, Haiming
收藏  |  浏览/下载：31/0  |  提交时间：2020/10/26
ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle 期刊论文
PLOS BIOLOGY, 2020, 卷号: 18
作者:  Li, Zhiyuan;  Tian, Xiaofei;  Ji, Xinmiao;  Wang, Junjun;  Chen, Hanxiao;  Wang, Dongmei;  Zhang, Xin
收藏  |  浏览/下载：74/0  |  提交时间：2020/10/29
Combining mutagenesis on Glu281 of prenyltransferase NovQ and metabolic engineering strategies for the increased prenylated activity towards menadione 期刊论文
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020
作者:  Ni, Wenfeng;  Zheng, Zhiming;  Liu, Hui;  Wang, Peng;  Wang, Han;  Sun, Xiaowen;  Yang, Qiang;  Fang, Zhiwei;  Tang, Hengfang;  Zhao, Genhai
收藏  |  浏览/下载：215/0  |  提交时间：2020/11/26
Prenyltransferase NovQ  Menadione hydroquinol  Site-directed mutagenesis  Mevalonate pathway  Metabolic engineering  
Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion 期刊论文
FASEB JOURNAL, 2018, 卷号: 32, 期号: 5, 页码: 2411-2421
作者:  Xin, Yanlong;  Zhao, Yan;  Zheng, Jiangge;  Zhou, Haizhen;  Zhang, Xuejun Cai;  Tian, Changlin;  Huang, Yihua
浏览  |  Adobe PDF(1647Kb)  |  收藏  |  浏览/下载：105/35  |  提交时间：2019/08/23
X-ray crystallography  YidC/Oxa1/Alb3  membrane protein insertase  membrane protein biogenesis  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：598/506  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibi 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018
作者:  Qiang Wang;  Feiyang Liu;  Qi S(亓爽);  Ziping Qi;  Beilei Wang;  Aoli Wang;  Zongru Jiang;  Wenchao Wang;  Qingsong Liu;  Jing Liu
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：135/55  |  提交时间：2020/10/20
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：86/31  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21284/11467  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
高尔基体蛋白STK16和G蛋白GNG7在有丝分裂和膜转运中的功能研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  刘娟娟
Adobe PDF(6840Kb)  |  收藏  |  浏览/下载：55/3  |  提交时间：2018/01/18