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HFCAS OpenIR

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BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer 期刊论文
ANTIOXIDANTS, 2022, 卷号: 11
作者:  Lv, Yang;  Lv, Xiaotong;  Zhang, Jiahui;  Cao, Guozhen;  Xu, Changzhi;  Zhang, Buchang;  Lin, Wenchu
收藏  |  浏览/下载：53/0  |  提交时间：2022/05/16
small cell lung cancer  BRD4  KEAP1  Nrf2  pentose phosphate pathway  
Integrated Transcriptomics and Reverse Pharmacophore Mapping-based Network Pharmacology to Explore the Mechanisms of Natural Compounds against Doxorubicin-induced Cardiotoxicity 期刊论文
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2022, 卷号: 25
作者:  Zhu, Junfeng;  Yi, Xiaojiao;  Ding, Haiying;  Zhong, Like;  Fang, Luo
收藏  |  浏览/下载：46/0  |  提交时间：2022/12/22
Doxorubicin-induced cardiotoxicity  natural compounds  mechanism of action  gene expression profile  bioinformatics  network pharmacology  
FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021
作者:  Yin, Yan-ping;  Ma, Li-ying;  Cao, Guo-zhen;  Hua, Jing-han;  Lv, Xiao-tong;  Lin, Wen-chu
收藏  |  浏览/下载：72/0  |  提交时间：2022/01/10
small cell lung cancer  topotecan  DNA damage response  FK228  SLFN11  methylation  epigenetic modulation  
Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:  Fu, Weitao;  Zhang, Minkui;  Liao, Jianing;  Tang, Qing;  Lei, Yixuan;  Gong, Zhou;  Shan, Luhu;  Duan, Mojie;  Chai, Xin;  Pang, Jinping;  Tang, Chun;  Wang, Xuwen;  Xu, Xiaohong;  Li, Dan;  Sheng, Rong;  Hou, Tingjun
收藏  |  浏览/下载：56/0  |  提交时间：2022/03/21
Identification of FPR3 as a Unique Biomarker for Targeted Therapy in the Immune Microenvironment of Breast Cancer 期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 11
作者:  Qi, Jian;  Liu, Yu;  Hu, Jiliang;  Lu, Li;  Dou, Zhen;  Dai, Haiming;  Wang, Hongzhi;  Yang, Wulin
收藏  |  浏览/下载：47/0  |  提交时间：2021/04/26
breast cancer  immune microenvironment  ESTIMATE algorithm  immune checkpoint  FPR3  
Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted Gene Co-Expression Network 期刊论文
JOURNAL OF IMMUNOLOGY RESEARCH, 2020, 卷号: 2020
作者:  Qian, Xiang;  Chen, Zhuo;  Chen, Sha Sha;  Liu, Lu Ming;  Zhang, Ai Qin
收藏  |  浏览/下载：48/0  |  提交时间：2020/11/26
Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems 期刊论文
CURRENT MEDICINAL CHEMISTRY, 2018, 卷号: 25, 期号: 25, 页码: 3036-3057
作者:  Sun, Xiao;  Zhang, Guilong;  Wu, Zhengyan
浏览  |  Adobe PDF(4176Kb)  |  收藏  |  浏览/下载：97/50  |  提交时间：2019/12/25
pH-responsive  magnetic resonance contrast agents  drug delivery systems  contrast enhancement  controlled release  cancer diagnosis and chemotherapy  
N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts 期刊论文
CELLULAR MICROBIOLOGY, 2018, 卷号: 20, 期号: 1, 页码: 15
作者:  Neely, Aaron M.;  Zhao, Guoping;  Schwarzer, Christian;  Stivers, Nicole S.;  Whitt, Aaron G.;  Meng, Shuhan;  Burlison, Joseph A.;  Machen, Terry E.;  Li, Chi
浏览  |  Adobe PDF(4353Kb)  |  收藏  |  浏览/下载：99/36  |  提交时间：2019/02/28
homoserine lactone  apoptosis  caspase  mitochondria  
新型不可逆BTK激酶抑制剂的发现研究 学位论文
, 北京: 中国科学院研究生院, 2017
作者:  邓远欣
Adobe PDF(2196Kb)  |  收藏  |  浏览/下载：635/1  |  提交时间：2018/01/17
氘氚中子发生器脉冲系统设计及控制方法的研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  孔令立
Adobe PDF(2658Kb)  |  收藏  |  浏览/下载：46/0  |  提交时间：2018/01/18