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HFCAS OpenIR

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Two coexisting pseudo-mirror heteromolecular telomeric G-quadruplexes in opposite loop progressions differentially recognized by a low equivalent of Thioflavin T 期刊论文
NUCLEIC ACIDS RESEARCH, 2021, 卷号: 49
作者:  Fu, Wenqiang;  Jing, Haitao;  Xu, Xiaojuan;  Xu, Suping;  Wang, Tao;  Hu, Wenxuan;  Li, Huihui;  Zhang, Na
收藏  |  浏览/下载：64/0  |  提交时间：2022/01/10
Phospho-regulation and function of ULK1-ATG13 during the cell cycle 期刊论文
AUTOPHAGY, 2021
作者:  Li, Zhiyuan;  Zhang, Xin
收藏  |  浏览/下载：51/0  |  提交时间：2021/04/26
ULK1  ATG13  CDK1  autophagy  mitosis  
NMR structural study on the self-trimerization of d(GTTAGG) into a dynamic trimolecular G-quadruplex assembly preferentially in Na+ solution with a moderate K+ tolerance 期刊论文
NUCLEIC ACIDS RESEARCH, 2021, 卷号: 49
作者:  Jing, Haitao;  Fu, Wenqiang;  Hu, Wenxuan;  Xu, Suping;  Xu, Xiaojuan;  He, Miao;  Liu, Yangzhong;  Zhang, Na
收藏  |  浏览/下载：59/0  |  提交时间：2021/06/15
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:  Wang, Wen-liang;  Jiang, Zong-ru;  Hu, Chen;  Chen, Cheng;  Hu, Zhen-quan;  Wang, Ao-li;  Wang, Li;  Liu, Jing;  Wang, Wen-chao;  Liu, Qing-song
收藏  |  浏览/下载：66/0  |  提交时间：2020/11/26
PGK1  NG52  kinase inhibitor  Warburg effect  glioma  
ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle 期刊论文
PLOS BIOLOGY, 2020, 卷号: 18
作者:  Li, Zhiyuan;  Tian, Xiaofei;  Ji, Xinmiao;  Wang, Junjun;  Chen, Hanxiao;  Wang, Dongmei;  Zhang, Xin
收藏  |  浏览/下载：75/0  |  提交时间：2020/10/29
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:  Liang, Xiaofei;  Jiang, Zongru;  Huang, Zhenghui;  Li, Feng;  Chen, Cheng;  Hu, Chen;  Wang, Wenliang;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Qi, Ziping;  Liu, Jing;  Jiang, Lubin;  Liu, Qingsong
收藏  |  浏览/下载：65/0  |  提交时间：2020/11/26
PI4K kinase  Kinase inhibitor  Malaria  Blood stage  Liver stage  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：202/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：32/0  |  提交时间：2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia  
Dopamine Receptor Subtypes Differentially Regulate Autophagy 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 5, 页码: 16
作者:  Wang, Dongmei;  Ji, Xinmiao;  Liu, Juanjuan;  Li, Zhiyuan;  Zhang, Xin
收藏  |  浏览/下载：35/0  |  提交时间：2019/11/11
dopamine receptor  autophagy  AKT  mTOR  AMPK  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：91/31  |  提交时间：2019/06/17