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HFCAS OpenIR

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S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 71
作者:  Li, Haobin;  Cai, Maohua;  Cao, Fei;  Yu, Dehua;  Yang, Jing;  Yu, Wenkai;  Chu, Chu;  Guan, Xiaoqing;  Qin, Jiang-Jiang;  Dong, Jinyun
收藏  |  浏览/下载：43/0  |  提交时间：2022/12/22
STAT3 inhibitor  Quinone derivative  S3I-201  Anti -gastric cancer drug  
Targeting KRAS mutant cancers: from druggable therapy to drug resistance 期刊论文
MOLECULAR CANCER, 2022, 卷号: 21
作者:  Zhu, Chunxiao;  Guan, Xiaoqing;  Zhang, Xinuo;  Luan, Xin;  Song, Zhengbo;  Cheng, Xiangdong;  Zhang, Weidong;  Qin, Jiang-Jiang
收藏  |  浏览/下载：36/0  |  提交时间：2022/12/23
KRAS mutations  Druggable  Resistance  Combination therapy  
Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer 期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
作者:  Yu, Dehua;  Qi, Simin;  Guan, Xiaoqing;  Yu, Wenkai;  Yu, Xuefei;  Cai, Maohua;  Li, Qinglin;  Wang, Weiyi;  Zhang, Weidong;  Qin, Jiang-Jiang
收藏  |  浏览/下载：33/0  |  提交时间：2022/12/23
STAT3  inhibitor  natural product  gastric cancer  terphenyllin  
Protein degradation technology: a strategic paradigm shift in drug discovery 期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 卷号: 14
作者:  Li, Haobin;  Dong, Jinyun;  Cai, Maohua;  Xu, Zhiyuan;  Cheng, Xiang-Dong;  Qin, Jiang-Jiang
收藏  |  浏览/下载：66/0  |  提交时间：2021/11/01
Protein degradation  Degradation pathway  Degradation technology  PROTAC  Monomeric degraders  
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:  Dong, Jinyun;  Cheng, Xiang-Dong;  Zhang, Wei-Dong;  Qin, Jiang-Jiang
收藏  |  浏览/下载：59/0  |  提交时间：2021/08/31
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy 期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12
作者:  Qi, Si-Min;  Dong, Jinyun;  Xu, Zhi-Yuan;  Cheng, Xiang-Dong;  Zhang, Wei-Dong;  Qin, Jiang-Jiang
收藏  |  浏览/下载：52/0  |  提交时间：2021/06/15
PROTAC  E3 ubiquitin ligase  protein degradation  ubiquitin-proteasome system  cancer therapy  
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges 期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:  Yu, De-Hua;  Xu, Zhi-Yuan;  Mo, Shaowei;  Yuan, Li;  Cheng, Xiang-Dong;  Qin, Jiang-Jiang
收藏  |  浏览/下载：26/0  |  提交时间：2020/10/26
MDMX  MDM2  p53  oncogene  tumor suppressor  inhibitors  
Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Pathways Associated With Clinical Outcome in Hepatocellular Carcinoma 期刊论文
FRONTIERS IN GENETICS, 2020, 卷号: 11
作者:  Li, Yubin;  Chen, Runzhe;  Yang, Jian;  Mo, Shaowei;  Quek, Kelly;  Kok, Chung H.;  Cheng, Xiang-Dong;  Tian, Saisai;  Zhang, Weidong;  Qin, Jiang-Jiang
收藏  |  浏览/下载：38/0  |  提交时间：2020/10/26
hepatocellular carcinoma  differentially expression genes  enrichment analysis  survival analysis  prognosis  
Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2020, 卷号: 83
作者:  Wang, Weiyi;  Yang, Jing;  Liao, Yan-Yan;  Cheng, Gang;  Chen, Jing;  Cheng, Xiang-Dong;  Qin, Jiang-Jiang;  Shao, Zongze
收藏  |  浏览/下载：50/0  |  提交时间：2020/11/26
Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice 期刊论文
FRONTIERS IN PHARMACOLOGY, 2020, 卷号: 11
作者:  Zhang, Jia;  Wang, Weiyi;  Zhou, Yuan;  Yang, Jing;  Xu, Jingli;  Xu, Zhiyuan;  Xu, Beihua;  Yan, Li;  Cheng, Xiang-Dong;  Li, Minghua;  Qin, Jiang-Jiang
收藏  |  浏览/下载：55/0  |  提交时间：2020/11/26
terphenyllin  pancreatic cancer  metastasis  Bax  Bcl-2  Puma