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HFCAS OpenIR

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Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation 期刊论文
NANOTOXICOLOGY, 2022
作者:  Wu, Tao;  Xu, Shengmin;  Chen, Biao;  Bao, Lingzhi;  Ma, Jie;  Han, Wei;  Xu, An;  Yu, Kwan Ngok;  Wu, Lijun;  Chen, Shaopeng
收藏  |  浏览/下载：48/0  |  提交时间：2022/12/23
PM2  5  senescence  cGAS  micronuclei  DNA damage  
FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021
作者:  Yin, Yan-ping;  Ma, Li-ying;  Cao, Guo-zhen;  Hua, Jing-han;  Lv, Xiao-tong;  Lin, Wen-chu
收藏  |  浏览/下载：74/0  |  提交时间：2022/01/10
small cell lung cancer  topotecan  DNA damage response  FK228  SLFN11  methylation  epigenetic modulation  
Editorial: The Role of Different Subcellular Organelles in DNA Damage Response 期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 卷号: 9
作者:  Zhao, Guoping
收藏  |  浏览/下载：67/0  |  提交时间：2022/01/10
DNA damage repair  subcellular organelles  mitochondria  lysosomes  crosstalk  
FK228 sensitizes radioresistant small cell lung cancer cells to radiation 期刊论文
CLINICAL EPIGENETICS, 2021, 卷号: 13
作者:  Li, Hong;  Ma, Liying;  Bian, Xing;  Lv, Yang;  Lin, Wenchu
收藏  |  浏览/下载：48/0  |  提交时间：2021/04/26
Small cell lung cancer  FK228  Histone deacetylase  PI3K  Radioresistance  DNA damage repair  
Mutagenicity of 7-ketocholesterol in CHO cells: The role of lipid peroxidation 期刊论文
TOXICOLOGY, 2020, 卷号: 446
作者:  Wang, Xiaofei;  Li, Yintao;  Xia, Xuanyi;  Zhang, Min;  Ge, Chunmei;  Xia, Xiaoxiao;  Xiao, Hourong;  Xu, Shengmin
收藏  |  浏览/下载：58/0  |  提交时间：2020/12/28
7-ketocholesterol  Mutagenicity  DNA damage  Apoptosis  Lipid peroxidation  
The MYC Paralog-PARP1 Axis as a Potential TherapeuticTarget in MYC Paralog-Activated Small Cell Lung Cancer 期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:  Bian, Xing;  Wang, Xiaolin;  Zhang, Qiuyan;  Ma, Liying;  Cao, Guozhen;  Xu, Ao;  Han, Jinhua;  Huang, Jun;  Lin, Wenchu
收藏  |  浏览/下载：52/0  |  提交时间：2020/11/30
small cell lung cancer  MYCparalog  PARP1  BET  DNA damage response  
Genotoxicity of microcystin-LR in mammalian cells: Implication from peroxynitrite produced by mitochondria 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 卷号: 195
作者:  Wang, Xiaofei;  Li, Yintao;  Xiao, Hourong;  Zhang, Min;  Bao, Teng;  Luo, Xun;  Chen, Shaopeng
收藏  |  浏览/下载：43/0  |  提交时间：2020/11/26
Microcystin-LR  DNA damage  Peroxynitrite  Mitochondria  
LncRNAs in DNA damage response and repair in cancer cells 期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50
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收藏  |  浏览/下载：28/0  |  提交时间：2020/10/26
LONG NONCODING RNA  CISPLATIN-INDUCED NEPHROTOXICITY  STRAND BREAK REPAIR  NASOPHARYNGEAL CARCINOMA  HOMOLOGOUS RECOMBINATION  MESENCHYMAL TRANSITION  REPLICATION STRESS  PANCREATIC-CANCER  COLORECTAL-CANCER  GENOME INTEGRITY  DNA damage response  apoptosis  cell cycle  cancer  lncRNA  
Advances in The Research of P53 Pulses 期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2015, 卷号: 42
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收藏  |  浏览/下载：40/0  |  提交时间：2020/10/26
DNA-DAMAGE RESPONSE  P53-MDM2 FEEDBACK LOOP  CELL-FATE  SINGLE CELLS  REGULATORY NETWORK  DYNAMICS  DEATH  OSCILLATIONS  ACTIVATION  THRESHOLD  P53 pulses  DNA damage  p53-Mdm2 negative feedback loop  dynamics  threshold  cell fate  
An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma 期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2015, 卷号: 13
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收藏  |  浏览/下载：42/0  |  提交时间：2020/10/26
RECURRENT SOMATIC MUTATIONS  ONCOGENE-INDUCED SENESCENCE  YES-ASSOCIATED PROTEIN  COPY-NUMBER ALTERATION  DNA-DAMAGE RESPONSE  GENE-EXPRESSION  WIDE ANALYSIS  CANCER  INSTABILITY  P53