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HFCAS OpenIR

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Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022
作者:  Jin, Cheng;  Ei-Sagheer, Afaf H.;  Li, Siqi;  Vallis, Katherine A.;  Tan, Weihong;  Brown, Tom
收藏  |  浏览/下载：74/0  |  提交时间：2022/03/21
Cathepsin B  DNA Breakage  Dipeptide Linker  Oligonucleotide-Drug Conjugates  Solid-Phase Synthesis  
Programmable Repurposing of Existing Drugs as Pharmaceutical Elements for the Construction of Aptamer-Drug Conjugates 期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2021, 卷号: 13
作者:  Gao, Fei;  Zhou, Jinming;  Sun, Yang;  Yang, Cai;  Zhang, Shiyan;  Wang, Ruowen;  Tan, Weihong
收藏  |  浏览/下载：50/0  |  提交时间：2021/04/26
aptamer  pharmaceutical elements  solid-phase synthesis  targeted therapy  drug delivery  
Chemical synthesis and structural analysis of guanylate cyclase C agonist linaclotide 期刊论文
CHINESE CHEMICAL LETTERS, 2018, 卷号: 29
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收藏  |  浏览/下载：26/0  |  提交时间：2020/10/26
IRRITABLE-BOWEL-SYNDROME  RACEMIC PROTEIN CRYSTALLOGRAPHY  X-RAY STRUCTURES  GASTROINTESTINAL-TRACT  PREVALENCE  LIGATION  PATTERNS  IMPACT  Linaclotide  Guanylyl cyclase  Protein chemical synthesis  Fmoc solid phase peptide synthesis  Racemic crystallization  
Recent Advances in Chemical Synthesis of Backbone Cyclized Peptides 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2014, 卷号: 34
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收藏  |  浏览/下载：38/0  |  提交时间：2020/10/26
SOLID-PHASE SYNTHESIS  KINETICALLY CONTROLLED LIGATION  TO-TAIL CYCLIZATION  BIOMIMETIC SYNTHESIS  STAUDINGER LIGATION  CYCLATIVE CLEAVAGE  THIOESTER  PROTEINS  TETRAPEPTIDES  CYCLOTETRAPEPTIDES  backbone cyclized peptides  chemical synthesis  native chemical ligation