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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：196/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：29/0  |  提交时间：2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia  
Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy 期刊论文
MOLECULAR THERAPY, 2018, 卷号: 26, 期号: 10, 页码: 2456-2465
作者:  Sun, Yuxiang;  Dai, Hui;  Chen, Shaopeng;  Zhang, Yajun;  Wu, Tao;  Cao, Xianbin;  Zhao, Guoping;  Xu, An;  Wang, Jun;  Wu, Lijun
收藏  |  浏览/下载：30/0  |  提交时间：2019/12/25
Effective pH-Activated Theranostic Platform for Synchronous Magnetic Resonance Imaging Diagnosis and Chemotherapy 期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2018, 卷号: 10, 期号: 37, 页码: 31114-31123
作者:  Wang, Dan;  Lin, Haiyan;  Zhang, Guilong;  Si, Yuanchun;  Yang, Hongyi;  Bai, Guo;  Yang, Chi;  Zhong, Kai;  Cai, Dongqing;  Wu, Zhengyan;  Wang, Renfei;  Zou, Duohong
收藏  |  浏览/下载：64/0  |  提交时间：2019/12/20
pH-activated  synchronous  MRI  theranostic platform  tumor chemotherapy  
In Situ One-Pot Synthesis of MOF-Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy 期刊论文
ADVANCED SCIENCE, 2018, 卷号: 5, 期号: 6, 页码: 8
作者:  Wang, Dongdong;  Wu, Huihui;  Zhou, Jiajia;  Xu, Pengping;  Wang, Changlai;  Shi, Ruohong;  Wang, Haibao;  Wang, Hui;  Guo, Zhen;  Chen, Qianwang
收藏  |  浏览/下载：44/0  |  提交时间：2019/11/11
cancer theranostics  metal-organic framework-polymer  multimodal imaging  nanogels  photothermal effects