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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
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ABL kinase  Kinase inhibitor  ABL mutant  CML  
Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells 期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 658, 页码: 54-65
Authors:  Ma, Jie;  Yu, K. N.;  Cheng, Cheng;  Ni, Guohua;  Shen, Jie;  Han, Wei
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Non-thermal plasma  Reactive oxygen species  Heme oxygenase-1  Apoptotic death  c-JUN N-terminal kinase  
N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes 期刊论文
CHEMOSPHERE, 2018, 卷号: 204, 期号: 无, 页码: 463-473
Authors:  Zhao, Sujuan;  Liu, Ying;  Wang, Fang;  Xu, Dexiang;  Xie, Ping
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Microcystin  Endoplasmic reticulum stress  Apoptosis  N-acetylcysteine (NAC)  Zebrafish testes  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
Authors:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
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PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts 期刊论文
CELLULAR MICROBIOLOGY, 2018, 卷号: 20, 期号: 1, 页码: 15
Authors:  Neely, Aaron M.;  Zhao, Guoping;  Schwarzer, Christian;  Stivers, Nicole S.;  Whitt, Aaron G.;  Meng, Shuhan;  Burlison, Joseph A.;  Machen, Terry E.;  Li, Chi
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homoserine lactone  apoptosis  caspase  mitochondria  
Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy 期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 卷号: 546, 期号: 1-2, 页码: 215-225
Authors:  Li, Jun;  Liang, Huamin;  Liu, Jing;  Wang, Ziyuan
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Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
Authors:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
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Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
Authors:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
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Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 49, 页码: 86312-86324
Authors:  Wang, Huogang;  Hong, Bo;  Li, Xuemin;  Deng, Ke;  Li, Hong;  Lui, Vivian Wai Yan;  Lin, Wenchu
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Small Cell Lung Cancer  N-myc  Bcl-2  Jq1  Abt-263  
Kinases Involved in Both Autophagy and Mitosis 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 卷号: 18, 期号: 9, 页码: 1-15
Authors:  Li, Zhiyuan;  Zhang, Xin
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Kinases  Autophagy  Mitosis  Cyclin-dependent Kinases  Aurora  Polo-like Kinases