HFCAS OpenIR

Browse/Search Results:  1-10 of 25 Help

Selected(0)Clear Items/Page:    Sort:
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
Authors:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
View  |  Adobe PDF(6587Kb)  |  Favorite  |  View/Download:99/93  |  Submit date:2019/08/23
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
Authors:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
View  |  Adobe PDF(10028Kb)  |  Favorite  |  View/Download:12/5  |  Submit date:2019/06/17
新型不可逆BTK激酶抑制剂的发现研究 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  邓远欣
Adobe PDF(2196Kb)  |  Favorite  |  View/Download:532/1  |  Submit date:2018/01/17
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
Authors:  Wang, Beilei;  Deng, Yuanxin;  Chen, Yongfei;  Yu, Kailin;  Wang, Aoli;  Liang, Qianmao;  Wang, Wei;  Chen, Cheng;  Wu, Hong;  Hu, Chen;  Miao, Weili;  Hur, Wooyoung;  Wang, Wenchao;  Hu, Zhenquan;  Weisberg, Ellen L.;  Wang, Jinhua;  Ren, Tao;  Wang, Yinsheng;  Gray, Nathanael S.;  Liu, Qingsong;  Liu, Jing
Favorite  |  View/Download:79/0  |  Submit date:2018/08/16
Btk  Kinase Inhibitor  Irreversible Inhibitor  Structure-activity Relationship  B-cell Lymphoma  
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl) phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 131, 页码: 107-125
Authors:  Liang, Qianmao;  Chen, Yongfei;  Yu, Kailin;  Chen, Cheng;  Zhang, Shouxiang;  Wang, Aoli;  Wang, Wei;  Wu, Hong;  Liu, Xiaochuan;  Wang, Beilei;  Wang, Li;  Hu, Zhenquan;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Yun, Cai-Hong;  Liu, Jing
Favorite  |  View/Download:9/0  |  Submit date:2018/07/26
Btk  Irreversible Inhibitor  Kinase Inhibitor  Structure-activity Relationship  B-cell Lymphoma  
针对FLT3-ITD阳性急性髓细胞白血病的激酶抑制剂药物学研究 学位论文
, 合肥: 中国科学技术大学, 2017
Authors:  王傲莉
Adobe PDF(7111Kb)  |  Favorite  |  View/Download:51/0  |  Submit date:2018/01/18
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-10
Authors:  Wu, Hong;  Huang, Qiong;  Qi, Ziping;  Chen, Yongfei;  Wang, Aoli;  Chen, Cheng;  Liang, Qianmao;  Wang, Jinghua;  Chen, Wensheng;  Dong, Jin;  Yu, Kailin;  Hu, Chen;  Wang, Wenchao;  Liu, Xiaochuan;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Li, Xiaoxiang;  Gray, Nathanael S.;  Liu, Jing;  Wei, Wei;  Liu, Qingsong
View  |  Adobe PDF(3966Kb)  |  Favorite  |  View/Download:28/6  |  Submit date:2018/07/04
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
Authors:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
View  |  Adobe PDF(5919Kb)  |  Favorite  |  View/Download:1863/1851  |  Submit date:2018/07/04
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 11, 页码: 18359-18372
Authors:  Hu, Chen;  Wang, Aoli;  Wu, Hong;  Qi, Ziping;  Li, Xixiang;  Yan, Xiao-E;  Chen, Cheng;  Yu, Kailin;  Zou, Fengming;  Wang, Wenchao;  Wang, Wei;  Wu, Jiaxin;  Liu, Juan;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
View  |  Adobe PDF(6153Kb)  |  Favorite  |  View/Download:101/6  |  Submit date:2018/07/04
Egfr  Egfrt790m  Nsclc  Kinase Inhibitors  Drug Resistance  
一种高活性高选择性Type Ⅱ不可逆 BMX 激酶抑制剂的开发 学位论文
, 合肥: 中国科学技术大学, 2017
Authors:  吕凤超
Adobe PDF(2693Kb)  |  Favorite  |  View/Download:9/0  |  Submit date:2018/01/18